| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 4 |
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| Ligand | BDBM50265667 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_558792 (CHEMBL1020786) |
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| IC50 | 430±n/a nM |
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| Citation |  Yokoyama, K; Ishikawa, N; Igarashi, S; Kawano, N; Masuda, N; Hamaguchi, W; Yamasaki, S; Koganemaru, Y; Hattori, K; Miyazaki, T; Ogino, S; Matsumoto, Y; Takeuchi, M; Ohta, M Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem17:64-73 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 4 |
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| Name: | C-C chemokine receptor type 4 |
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| Synonyms: | C-C CKR-4 | CC-CKR-4 | CCR-4 | CCR4_MOUSE | CD_antigen=CD194 | Ccr4 | Cmkbr4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41410.76 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_512157 |
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| Residue: | 360 |
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| Sequence: | MNATEVTDTTQDETVYNSYYFYESMPKPCTKEGIKAFGEVFLPPLYSLVFLLGLFGNSVV
VLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQWVFGLGLCKIVSWMYLVG
FYSGIFFIMLMSIDRYLAIVHAVFSLKARTLTYGVITSLITWSVAVFASLPGLLFSTCYT
EHNHTYCKTQYSVNSTTWKVLSSLEINVLGLLIPLGIMLFCYSMIIRTLQHCKNEKKNRA
VRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDCTLERYLDYAIQATETLAFIHCCLN
PVIYFFLGEKFRKYITQLFRTCRGPLVLCKHCDFLQVYSADMSSSSYTQSTVDHDFRDAL
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| BDBM50265667 |
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| n/a |
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| Name | BDBM50265667 |
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| Synonyms: | 1'-{4-[(4-Chlorophenyl)amino]-6,7-dimethoxyquinazolin-2-yl}-1,4'-bipiperidin-3-ol | CHEMBL496151 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H32ClN5O3 |
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| Mol. Mass. | 498.017 |
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| SMILES | COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N1CCCC(O)C1 |
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| Structure | 
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