Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 1 | ||
| Ligand | BDBM50265540 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_559889 (CHEMBL1010125) | ||
| IC50 | >25000±n/a nM | ||
| Citation |  Renhowe, PA; Pecchi, S; Shafer, CM; Machajewski, TD; Jazan, EM; Taylor, C; Antonios-McCrea, W; McBride, CM; Frazier, K; Wiesmann, M; Lapointe, GR; Feucht, PH; Warne, RL; Heise, CC; Menezes, D; Aardalen, K; Ye, H; He, M; Le, V; Vora, J; Jansen, JM; Wernette-Hammond, ME; Harris, AL Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors. J Med Chem52:278-92 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 1 | |||
| Name: | Fibroblast growth factor receptor 1 | ||
| Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr | ||
| Type: | Receptor | ||
| Mol. Mass.: | 91861.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11362 | ||
| Residue: | 822 | ||
| Sequence: |
| ||
| BDBM50265540 | |||
| n/a | |||
| Name | BDBM50265540 | ||
| Synonyms: | 4-Hydroxy-1-methyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one | CHEMBL496173 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H15N3O2 | ||
| Mol. Mass. | 305.3306 | ||
| SMILES | Cn1c(nc2ccccc12)-c1c(O)c2ccccc2n(C)c1=O |(-1.53,-7.9,;-1.86,-6.39,;-3.27,-5.77,;-3.11,-4.24,;-1.61,-3.91,;-.85,-2.58,;.68,-2.57,;1.46,-3.91,;.69,-5.24,;-.84,-5.24,;-4.59,-6.54,;-5.94,-5.76,;-5.95,-4.22,;-7.28,-6.55,;-8.61,-5.79,;-9.94,-6.56,;-9.94,-8.1,;-8.61,-8.87,;-7.27,-8.1,;-5.93,-8.87,;-5.93,-10.41,;-4.58,-8.09,;-3.25,-8.86,)| | ||
| Structure | 
| ||