Reaction Details | |||
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Target | Vascular endothelial growth factor receptor 2 | ||
Ligand | BDBM50265540 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_559888 (CHEMBL1010124) | ||
IC50 | >25000±n/a nM | ||
Citation | Renhowe, PA; Pecchi, S; Shafer, CM; Machajewski, TD; Jazan, EM; Taylor, C; Antonios-McCrea, W; McBride, CM; Frazier, K; Wiesmann, M; Lapointe, GR; Feucht, PH; Warne, RL; Heise, CC; Menezes, D; Aardalen, K; Ye, H; He, M; Le, V; Vora, J; Jansen, JM; Wernette-Hammond, ME; Harris, AL Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors. J Med Chem52:278-92 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Vascular endothelial growth factor receptor 2 | |||
Name: | Vascular endothelial growth factor receptor 2 | ||
Synonyms: | CD_antigen=CD309 | FLK1 | Fetal liver kinase 1 (FLK-1) | Flk-1/KDR | KDR | Kinase Insert Domain Receptor | Protein-tyrosine kinase receptor Flk-1 | VEGFR kinase (KDR) | VEGFR-2 | VEGFR-2 (KDR) | VEGFR2 | VGFR2_HUMAN | Vascular Endothelial Growth Factor Receptor Kinase 2 | Vascular endothelial growth factor receptor (VEGFR-2) | Vascular endothelial growth factor receptor 2 (KDR) | Vascular endothelial growth factor receptor 2 (VEGFR-2) | Vascular endothelial growth factor receptor 2 (VEGFR2) | Vascular endothelial growth factor receptor 2 precursor (VEGFR-2) | Vascular endothelial growth factor receptor-2 (VEGFR-2) | ||
Type: | Receptor Tyrosine Kinase | ||
Mol. Mass.: | 151510.97 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35968 | ||
Residue: | 1356 | ||
Sequence: |
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BDBM50265540 | |||
n/a | |||
Name | BDBM50265540 | ||
Synonyms: | 4-Hydroxy-1-methyl-3-(1-methyl-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one | CHEMBL496173 | ||
Type | Small organic molecule | ||
Emp. Form. | C18H15N3O2 | ||
Mol. Mass. | 305.3306 | ||
SMILES | Cn1c(nc2ccccc12)-c1c(O)c2ccccc2n(C)c1=O |(-1.53,-7.9,;-1.86,-6.39,;-3.27,-5.77,;-3.11,-4.24,;-1.61,-3.91,;-.85,-2.58,;.68,-2.57,;1.46,-3.91,;.69,-5.24,;-.84,-5.24,;-4.59,-6.54,;-5.94,-5.76,;-5.95,-4.22,;-7.28,-6.55,;-8.61,-5.79,;-9.94,-6.56,;-9.94,-8.1,;-8.61,-8.87,;-7.27,-8.1,;-5.93,-8.87,;-5.93,-10.41,;-4.58,-8.09,;-3.25,-8.86,)| | ||
Structure |