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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Vascular endothelial growth factor receptor 2 | ||
| Ligand | BDBM50265539 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_559888 (CHEMBL1010124) | ||
| IC50 | >25000±n/a nM | ||
| Citation |  Renhowe, PA; Pecchi, S; Shafer, CM; Machajewski, TD; Jazan, EM; Taylor, C; Antonios-McCrea, W; McBride, CM; Frazier, K; Wiesmann, M; Lapointe, GR; Feucht, PH; Warne, RL; Heise, CC; Menezes, D; Aardalen, K; Ye, H; He, M; Le, V; Vora, J; Jansen, JM; Wernette-Hammond, ME; Harris, AL Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors. J Med Chem52:278-92 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Vascular endothelial growth factor receptor 2 | |||
| Name: | Vascular endothelial growth factor receptor 2 | ||
| Synonyms: | CD_antigen=CD309 | FLK1 | Fetal liver kinase 1 (FLK-1) | Flk-1/KDR | KDR | Kinase Insert Domain Receptor | Protein-tyrosine kinase receptor Flk-1 | VEGFR kinase (KDR) | VEGFR-2 | VEGFR-2 (KDR) | VEGFR2 | VGFR2_HUMAN | Vascular Endothelial Growth Factor Receptor Kinase 2 | Vascular endothelial growth factor receptor (VEGFR-2) | Vascular endothelial growth factor receptor 2 (KDR) | Vascular endothelial growth factor receptor 2 (VEGFR-2) | Vascular endothelial growth factor receptor 2 (VEGFR2) | Vascular endothelial growth factor receptor 2 precursor (VEGFR-2) | Vascular endothelial growth factor receptor-2 (VEGFR-2) | ||
| Type: | Receptor Tyrosine Kinase | ||
| Mol. Mass.: | 151510.97 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P35968 | ||
| Residue: | 1356 | ||
| Sequence: |
| ||
| BDBM50265539 | |||
| n/a | |||
| Name | BDBM50265539 | ||
| Synonyms: | 4-hydroxy-3-(1-methyl-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one | CHEMBL496172 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H13N3O2 | ||
| Mol. Mass. | 291.304 | ||
| SMILES | Cn1c(nc2ccccc12)-c1c(O)c2ccccc2[nH]c1=O |(24.88,1.17,;24.55,2.67,;23.14,3.29,;23.3,4.82,;24.81,5.15,;25.56,6.48,;27.09,6.49,;27.87,5.16,;27.11,3.82,;25.57,3.82,;21.82,2.52,;20.47,3.3,;20.46,4.84,;19.13,2.51,;17.8,3.28,;16.47,2.5,;16.47,.96,;17.8,.19,;19.14,.96,;20.48,.19,;21.83,.97,;23.16,.2,)| | ||
| Structure | 
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