| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor X |
|---|
| Ligand | BDBM35743 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_516018 (CHEMBL981507) |
|---|
| Ki | 8.77±n/a nM |
|---|
| Citation |  Nagata, T; Yoshino, T; Haginoya, N; Yoshikawa, K; Nagamochi, M; Kobayashi, S; Komoriya, S; Yokomizo, A; Muto, R; Yamaguchi, M; Osanai, K; Suzuki, M; Kanno, H Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: a novel, potent and orally active direct inhibitor of factor Xa. Bioorg Med Chem17:1193-206 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor X |
|---|
| Name: | Coagulation factor X |
|---|
| Synonyms: | Coagulation factor X precursor | F10 | FA10_RAT | Factor Xa (fXa) | Stuart factor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54255.03 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | n/a |
|---|
| Residue: | 482 |
|---|
| Sequence: | MESPVRLSLLYVVLASLLLPGRSVFINRERANNVLQRIRRANSFFEEIKKGNLERECVEE
ICSFEEAREVFEDNEKTTEFWNKYEDGDQCESSPCQNQGECRDGLGSYTCTCTEGFEGKN
CELFVRKLCSLDNGDCDQFCREEQNSVVCSCAKGYFLGNDGKSCLSTAPFPCGKTNKGRA
KRSVALNTSNSEPDPEDLMPDADILYPTESPSELLNLNKTEPEANSDDVIRIVGGQECKR
GECPWQALLFSDEETDGFCGGTILNEFYILTAAHCLHQAKRFKVRVGDLNTEQEDGGEMV
HEVDMIIKHNKFQRDTYDFDIAMLRLKTPITFRENVAPACLPQKDWAEATLMTQKTGIVS
GFGRTHEKGRQSKVLKMMEVPYVDRNTCRLSTSFSITQNMFCAGYDAKQEDACQGDSGGP
HVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKARVGPTSETPRLTHP
PY
|
|
|
|---|
| BDBM35743 |
|---|
| n/a |
|---|
| Name | BDBM35743 |
|---|
| Synonyms: | CHEMBL479863 | cis-1,2-diaminocyclohexane derivative, A |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H31ClN6O3S |
|---|
| Mol. Mass. | 543.081 |
|---|
| SMILES | CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
