Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50248474 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_543051 (CHEMBL1021292) |
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IC50 | 250±n/a nM |
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Citation | Wang, H; Yu, N; Song, H; Chen, D; Zou, Y; Deng, W; Lye, PL; Chang, J; Ng, M; Sun, ET; Sangthongpitag, K; Wang, X; Wu, X; Khng, HH; Fang, L; Goh, SK; Ong, WC; Bonday, Z; Stünkel, W; Poulsen, A; Entzeroth, M N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity. Bioorg Med Chem Lett19:1403-8 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50248474 |
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n/a |
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Name | BDBM50248474 |
Synonyms: | CHEMBL491490 | N-hydroxy-3-(1-(3-morpholinopropyl)-2-phenethyl-1H-benzo[d]imidazol-5-yl)acrylamide | US10201527, Compound 31 | US10736881, Compound 31 | US8551988, 31 |
Type | Small organic molecule |
Emp. Form. | C25H30N4O3 |
Mol. Mass. | 434.5307 |
SMILES | ONC(=O)\C=C\c1ccc2n(CCCN3CCOCC3)c(CCc3ccccc3)nc2c1 |
Structure |
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