| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50248390 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_565879 (CHEMBL959302) |
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| EC50 | 380±n/a nM |
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| Citation |  Nishimura, T; Iino, T; Mitsuya, M; Bamba, M; Watanabe, H; Tsukahara, D; Kamata, K; Sasaki, K; Ohyama, S; Hosaka, H; Futamura, M; Nagata, Y; Eiki, J Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators. Bioorg Med Chem Lett19:1357-60 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50248390 |
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| n/a |
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| Name | BDBM50248390 |
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| Synonyms: | 5-(1H-imidazol-2-ylthio)-2-amino-N-(4-methylthiazol-2-yl)benzamide | CHEMBL489334 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13N5OS2 |
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| Mol. Mass. | 331.416 |
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| SMILES | Cc1csc(NC(=O)c2cc(Sc3ncc[nH]3)ccc2N)n1 |
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| Structure | 
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