Reaction Details |
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Target | Hexokinase-4 |
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Ligand | BDBM50248535 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_565879 (CHEMBL959302) |
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EC50 | 330±n/a nM |
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Citation | Nishimura, T; Iino, T; Mitsuya, M; Bamba, M; Watanabe, H; Tsukahara, D; Kamata, K; Sasaki, K; Ohyama, S; Hosaka, H; Futamura, M; Nagata, Y; Eiki, J Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators. Bioorg Med Chem Lett19:1357-60 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hexokinase-4 |
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Name: | Hexokinase-4 |
Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
Type: | Enzyme |
Mol. Mass.: | 52175.81 |
Organism: | Homo sapiens (Human) |
Description: | P35557 |
Residue: | 465 |
Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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BDBM50248535 |
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n/a |
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Name | BDBM50248535 |
Synonyms: | 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide | 5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-2-(methylamino)-N-(4-methylthiazol-2-yl)benzamide | CHEMBL490961 |
Type | Small organic molecule |
Emp. Form. | C15H16N6OS2 |
Mol. Mass. | 360.457 |
SMILES | CNc1ccc(Sc2nncn2C)cc1C(=O)Nc1nc(C)cs1 |
Structure |
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