Ki Summary

Reaction Details

Report a problem with these data

Target

SHC-transforming protein 1

Ligand

BDBM50276324

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_542407 (CHEMBL1010644)

9500±n/a nM

Citation

Choi, WJ; Kim, SE; Stephen, AG; Weidlich, I; Giubellino, A; Liu, F; Worthy, KM; Bindu, L; Fivash, MJ; Nicklaus, MC; Bottaro, DP; Fisher, RJ; Burke, TR Identification of Shc Src homology 2 domain-binding peptoid-peptide hybrids. J Med Chem52:1612-8 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

SHC-transforming protein 1

Name:

SHC-transforming protein 1

Synonyms:

SHC | SHC1 | SHC1_HUMAN | SHCA

Type:

PROTEIN

Mol. Mass.:

62820.39

Organism:

Homo sapiens (Human)

Description:

ChEMBL_542407

Residue:

583

Sequence:

MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRE
LFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMA
EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEG
VVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL

BDBM50276324

n/a

Name

BDBM50276324

Synonyms:

4-((2S,5S,11S,14S)-1-amino-11-(3-amino-3-oxopropyl)-14-(4-(2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-5-isothiocyanatobenzoyl)piperazine-2-carboxamido)-2-(hydroxymethyl)-5-isobutyl-1,4,7,10,13-pentaoxo-3,6,9,12-tetraazapentadecan-15-yl)phenyl dihydrogen phosphate | CHEMBL501435

Type

Small organic molecule

Emp. Form.

C51H57N10O16PS

Mol. Mass.

1129.094

SMILES

CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)C1CN(CCN1)C(=O)c1cc(ccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)N=C=S)C(=O)N[C@@H](CO)C(N)=O |r,wU:4.4,12.17,wD:21.34,73.78,(20.3,.8,;21.63,.04,;22.97,.8,;21.64,-1.51,;22.97,-2.27,;22.98,-3.81,;21.65,-4.59,;20.32,-3.83,;21.66,-6.12,;20.33,-6.89,;20.34,-8.43,;21.68,-9.2,;19.01,-9.21,;17.67,-8.44,;17.66,-6.9,;16.33,-6.14,;15,-6.91,;16.32,-4.6,;19.01,-10.75,;17.68,-11.52,;16.34,-10.76,;17.69,-13.06,;19.03,-13.83,;20.35,-13.05,;21.68,-13.83,;23.02,-13.04,;23.01,-11.5,;24.34,-10.73,;25.68,-11.49,;27.02,-12.26,;26.45,-10.15,;24.92,-12.82,;21.66,-10.74,;20.34,-11.52,;16.35,-13.83,;15.02,-13.07,;15.02,-11.53,;13.68,-13.85,;12.34,-13.08,;11.02,-13.87,;11.03,-15.41,;12.36,-16.17,;13.69,-15.39,;9.68,-13.12,;9.66,-11.57,;8.35,-13.9,;8.36,-15.42,;7.02,-16.21,;5.68,-15.44,;5.67,-13.91,;7,-13.13,;6.63,-11.16,;5.1,-10.9,;4.13,-12.08,;2.61,-11.83,;2.07,-10.38,;.55,-10.12,;3.06,-9.2,;4.57,-9.46,;5.55,-8.25,;7.08,-8.53,;8.05,-7.34,;9.57,-7.58,;10.54,-6.4,;10.11,-9.04,;9.14,-10.22,;7.61,-9.97,;7.03,-17.75,;7.05,-19.29,;7.06,-20.83,;24.31,-1.49,;25.65,-2.27,;24.3,.05,;25.63,.82,;26.97,.06,;28.32,.83,;25.63,2.34,;26.96,3.13,;24.29,3.1,)|

Structure