Ki Summary

Reaction Details

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Target

SHC-transforming protein 1

Ligand

BDBM50276318

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_542407 (CHEMBL1010644)

8600±n/a nM

Citation

Choi, WJ; Kim, SE; Stephen, AG; Weidlich, I; Giubellino, A; Liu, F; Worthy, KM; Bindu, L; Fivash, MJ; Nicklaus, MC; Bottaro, DP; Fisher, RJ; Burke, TR Identification of Shc Src homology 2 domain-binding peptoid-peptide hybrids. J Med Chem52:1612-8 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

SHC-transforming protein 1

Name:

SHC-transforming protein 1

Synonyms:

SHC | SHC1 | SHC1_HUMAN | SHCA

Type:

PROTEIN

Mol. Mass.:

62820.39

Organism:

Homo sapiens (Human)

Description:

ChEMBL_542407

Residue:

583

Sequence:

MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRE
LFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMA
EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEG
VVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL

BDBM50276318

n/a

Name

BDBM50276318

Synonyms:

4-((2S,5S,11S,14S)-1-amino-11-(3-amino-3-oxopropyl)-14-((S)-2-(4-(2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-5-isothiocyanatobenzamido)butanamido)-4-methylpentanamido)-2-(hydroxymethyl)-5-isobutyl-1,4,7,10,13-pentaoxo-3,6,9,12-tetraazapentadecan-15-yl)phenyl dihydrogen phosphate | CHEMBL449680

Type

Small organic molecule

Emp. Form.

C56H67N10O17PS

Mol. Mass.

1215.227

SMILES

CC(C)C[C@H](NC(=O)CCCNC(=O)c1cc(ccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)N=C=S)C(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O |r,wU:79.83,wD:71.75,58.62,42.45,4.4,(9.46,-13.03,;10.8,-12.27,;12.13,-13.06,;10.82,-10.73,;12.16,-9.97,;12.19,-8.44,;10.86,-7.67,;10.86,-6.13,;9.52,-8.44,;8.19,-7.67,;6.85,-8.44,;5.52,-7.66,;4.19,-8.43,;2.86,-7.66,;4.19,-9.98,;5.51,-10.74,;5.51,-12.29,;4.18,-13.06,;2.85,-12.29,;2.85,-10.75,;.97,-10.07,;-.04,-11.25,;.49,-12.7,;-.5,-13.88,;-2.02,-13.6,;-3.01,-14.78,;-2.54,-12.16,;-1.55,-10.99,;-2.09,-9.53,;-1.08,-8.35,;-1.61,-6.91,;-.63,-5.73,;-1.15,-4.28,;.91,-6,;1.43,-7.44,;.44,-8.63,;6.85,-13.06,;8.18,-13.83,;9.51,-14.6,;13.49,-10.76,;13.47,-12.3,;14.83,-10,;16.15,-10.79,;16.14,-12.33,;17.46,-13.11,;17.44,-14.65,;18.79,-15.43,;20.12,-14.66,;21.45,-15.45,;21.43,-16.98,;21.41,-18.52,;22.98,-16.99,;19.91,-16.97,;20.12,-13.12,;18.79,-12.35,;17.49,-10.03,;17.51,-8.49,;18.82,-10.81,;20.16,-10.05,;21.49,-10.84,;22.83,-10.08,;24.15,-10.86,;24.14,-12.4,;25.49,-10.1,;20.18,-8.52,;18.85,-7.73,;21.52,-7.76,;21.53,-6.22,;22.87,-5.46,;24.19,-6.25,;22.89,-3.92,;24.23,-3.17,;25.56,-3.95,;26.9,-3.19,;28.21,-3.97,;26.92,-1.65,;24.25,-1.63,;22.92,-.84,;25.59,-.87,;25.61,.67,;24.28,1.45,;24.29,3,;26.95,1.42,;26.96,2.97,;28.27,.64,)|

Structure