Reaction Details |
| Report a problem with these data |
Target | C-C chemokine receptor type 2 |
---|
Ligand | BDBM50257994 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_566656 (CHEMBL960970) |
---|
IC50 | 0.100±n/a nM |
---|
Citation | Kothandaraman, S; Donnely, KL; Butora, G; Jiao, R; Pasternak, A; Morriello, GJ; Goble, SD; Zhou, C; Mills, SG; Maccoss, M; Vicario, PP; Ayala, JM; Demartino, JA; Struthers, M; Cascieri, MA; Yang, L Design, synthesis, and structure-activity relationship of novel CCR2 antagonists. Bioorg Med Chem Lett19:1830-4 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
C-C chemokine receptor type 2 |
---|
Name: | C-C chemokine receptor type 2 |
Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
Type: | Enzyme |
Mol. Mass.: | 41932.32 |
Organism: | Homo sapiens (Human) |
Description: | P41597 |
Residue: | 374 |
Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
|
|
|
BDBM50257994 |
---|
n/a |
---|
Name | BDBM50257994 |
Synonyms: | (1S,3R)-N-(3,5-bis(-trifluoromethyl)benzyl)-1-iso propyl-3-(3-methyltetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide | (1S,3R)-N-(3,5-bis(tri fluoromethyl)benzyl)-1-isopropyl-3-(3-methyltetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide | (1S,3R)-N-(3,5-bis(trifluoro methyl)benzyl)-1-isopropyl-3-(3-methyltetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide | (1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl )-1-isopropyl-3-(3-methyltetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide | CHEMBL494191 |
Type | Small organic molecule |
Emp. Form. | C24H32F6N2O2 |
Mol. Mass. | 494.5135 |
SMILES | CC(C)[C@@]1(CC[C@H](C1)NC1CCOCC1C)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r| |
Structure |
|