| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
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| Ligand | BDBM50293280 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_501261 (CHEMBL976163) |
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| IC50 | 87.0±n/a nM |
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| Citation |  Feng, Z; Chu, F; Guo, Z; Sun, P Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib. Bioorg Med Chem Lett19:2270-2 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 1 |
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| Name: | Prostaglandin G/H synthase 1 |
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| Synonyms: | Cox-1 | Cox1 | Cyclooxygenase-1 | PGH synthase 1 | PGH1_MOUSE | PGHS-1 | PHS 1 | Prostaglandin G/H synthase (cyclooxygenase) | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 | Ptgs1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69044.61 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_10575 |
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| Residue: | 602 |
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| Sequence: | MSRRSLSLWFPLLLLLLLPPTPSVLLADPGVPSPVNPCCYYPCQNQGVCVRFGLDNYQCD
CTRTGYSGPNCTIPEIWTWLRNSLRPSPSFTHFLLTHGYWLWEFVNATFIREVLMRLVLT
VRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDVQLLA
QQLLLRREFIPAPQGTNILFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNL
ERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPERQMAVGQEVFGLLPGL
MLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIVIEEYVQHLSGYFLQ
LKFDPELLFRAQFQYRNRIAMEFNHLYHWHPLMPNSFQVGSQEYSYEQFLFNTSMLVDYG
VEALVDAFSRQRAGRIGGGRNFDYHVLHVAVDVIKESREMRLQPFNEYRKRFGLKPYTSF
QELTGEKEMAAELEELYGDIDALEFYPGLLLEKCQPNSIFGESMIEMGAPFSLKGLLGNP
ICSPEYWKPSTFGGDVGFNLVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVLVRRST
EL
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| BDBM50293280 |
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| n/a |
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| Name | BDBM50293280 |
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| Synonyms: | 3-(4-(hydroxymethyl)phenyl)-4-(4-(methylsulfonyl)phenyl)-1-propyl-1H-pyrrol-2(5H)-one | CHEMBL469785 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23NO4S |
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| Mol. Mass. | 385.477 |
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| SMILES | CCCN1CC(=C(C1=O)c1ccc(CO)cc1)c1ccc(cc1)S(C)(=O)=O |c:5| |
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| Structure | 
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