| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50250099 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_498745 (CHEMBL1021937) |
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| IC50 | 2800±n/a nM |
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| Citation |  Suzuki, N; Suzuki, T; Ota, Y; Nakano, T; Kurihara, M; Okuda, H; Yamori, T; Tsumoto, H; Nakagawa, H; Miyata, N Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors. J Med Chem52:2909-22 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50250099 |
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| n/a |
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| Name | BDBM50250099 |
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| Synonyms: | (S)-7-(Biphenyl-3-ylamino)-7-oxo-6-(pyridine-3-carbonylamino)heptylboronic acid | CHEMBL449493 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28BN3O4 |
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| Mol. Mass. | 445.319 |
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| SMILES | OB(O)CCCCC[C@H](NC(=O)c1cccnc1)C(=O)Nc1cccc(c1)-c1ccccc1 |r| |
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| Structure | 
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