Ki Summary

Reaction Details

Report a problem with these data

Target

5-hydroxytryptamine receptor 4

Ligand

BDBM50060688

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_523353 (CHEMBL1006689)

>10000±n/a nM

Citation

Morelli, E; Gemma, S; Budriesi, R; Campiani, G; Novellino, E; Fattorusso, C; Catalanotti, B; Coccone, SS; Ros, S; Borrelli, G; Persico, M; Fiorini, I; Nacci, V; Ioan, P; Chiarini, A; Hamon, M; Cagnotto, A; Mennini, T; Fracasso, C; Colovic, M; Caccia, S; Butini, S Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships. J Med Chem52:3548-62 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 4

Name:

5-hydroxytryptamine receptor 4

Synonyms:

5-HT4 | 5-hydroxytryptamine receptor 4 | 5HT4R_CAVPO | HTR4 | Serotonin 4 (5-HT4) receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

43735.29

Organism:

GUINEA PIG

Description:

5-HT4 HTR4 GUINEA PIG::O70528

Residue:

388

Sequence:

MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRP
QPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
TVECGGQWESQCHPAASSPLVAAQPIDT

BDBM50060688

n/a

Name

BDBM50060688

Synonyms:

7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxaline | 7-fluoro-4-(4-methylpiperazin-1-yl)pyrrolo[1,2-a]quinoxaline | CHEMBL341474

Type

Small organic molecule

Emp. Form.

C16H17FN4

Mol. Mass.

284.3314

SMILES

CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12

Structure