| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tubulin--tyrosine ligase |
|---|
| Ligand | BDBM50293291 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_519880 (CHEMBL961245) |
|---|
| Kd | 3300±n/a nM |
|---|
| Citation |  Dal Piaz, F; Vassallo, A; Lepore, L; Tosco, A; Bader, A; De Tommasi, N Sesterterpenes as tubulin tyrosine ligase inhibitors. First insight of structure-activity relationships and discovery of new lead. J Med Chem52:3814-28 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tubulin--tyrosine ligase |
|---|
| Name: | Tubulin--tyrosine ligase |
|---|
| Synonyms: | TTL | TTL_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 43213.30 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_519880 |
|---|
| Residue: | 377 |
|---|
| Sequence: | MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLVQ
LVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIQPPI
SNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVH
VIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHL
TNHCIQKEYSKNYGKYEEGNEMFFKEFNQYLTSALNITLESSILLQIKHIIRNCLLSVEP
AISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFP
PPDVEQPQTQPAAFIKL
|
|
|
|---|
| BDBM50293291 |
|---|
| n/a |
|---|
| Name | BDBM50293291 |
|---|
| Synonyms: | 6alpha,15(S)-dihydroxy-23-oxo-labd-8(22),13(14),17-trien-16(S),19-olide | CHEMBL497037 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H36O5 |
|---|
| Mol. Mass. | 416.5503 |
|---|
| SMILES | C\C(CC[C@H]1C(=C)C[C@H](O)[C@H]2[C@@](C)(CCC[C@]12C)C=O)=C/[C@H](O)[C@H]1OC(=O)C=C1C |r,c:29| |
|---|
| Structure | 
|
|---|
Search and Browse
