| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-5 |
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| Ligand | BDBM50055247 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_519949 (CHEMBL954628) |
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| Ki | 126±n/a nM |
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| Citation |  Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor. J Med Chem52:3723-34 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid receptor subunit alpha-5 |
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| Name: | Gamma-aminobutyric acid receptor subunit alpha-5 |
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| Synonyms: | GABA A Alpha5Beta2Gamma2 | GABA A Alpha5Beta3Gamma2 | GABA A Alpha5m10Beta2Gamma2 | GABA A Alpha5m8Beta2Gamma2 | GABA A Alpha5m9Beta2Gamma2 | GABA A alpha5 | GABA A receptor alpha-5/beta-3/gamma-2 | GABA receptor alpha-5 subunit | GBRA5_RAT | Gabra-5 | Gabra5 | Gamma-aminobutyric acid receptor subunit alpha-5 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52350.79 |
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| Organism: | RAT |
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| Description: | GABA A alpha5 0 RAT::P19969 |
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| Residue: | 464 |
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| Sequence: | MDNGMLSRFIMTKTLLVFCISMTLSSHFGFSQMPTSSVQDETNDNITIFTRILDGLLDGY
DNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPL
NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDF
PMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTS
TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM
TTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAA
KIKKKERELILNKSTNAFTTGKLTHPPNIPKEQLPGGTGNAVGTASIRASEEKTSESKKT
YNSISKIDKMSRIVFPILFGTFNLVYWATYLNREPVIKGATSPK
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| BDBM50055247 |
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| n/a |
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| Name | BDBM50055247 |
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| Synonyms: | CHEMBL75306 | N-(4-Methoxy-benzyl)-2-(5-nitro-1H-indol-3-yl)-2-oxo-acetamide | N-(4-methoxybenzyl)-2-(5-nitro-1H-indol-3-yl)-2-oxoacetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15N3O5 |
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| Mol. Mass. | 353.3288 |
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| SMILES | COc1ccc(CNC(=O)C(=O)c2c[nH]c3ccc(cc23)[N+]([O-])=O)cc1 |
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| Structure | 
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