| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin receptor type B |
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| Ligand | BDBM50280989 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_64181 |
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| IC50 | 295±n/a nM |
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| Citation |  Mugrage, B; Moliterni, J; Robinson, L; Webb, RL; Shetty, SS; Lipson, KE; Chin, MH; Neale, R; Cioffi, C CGS 27830, a potent nonpeptide endothelin receptor antagonist Bioorg Med Chem Lett3:2099-2104 (1993) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin receptor type B |
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| Name: | Endothelin receptor type B |
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| Synonyms: | EDNRB_RAT | ENDOTHELIN B | ET-B | Ednrb | Endothelin receptor | Endothelin receptor non-selective type |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49483.43 |
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| Organism: | RAT |
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| Description: | ENDOTHELIN B EDNRB RAT::P21451 |
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| Residue: | 442 |
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| Sequence: | MQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSN
SSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
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| BDBM50280989 |
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| n/a |
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| Name | BDBM50280989 |
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| Synonyms: | 2,6-dimethyl-5-methyloxycarbonyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic anhydride | CGS-27830 | CHEMBL67074 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H30N4O11 |
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| Mol. Mass. | 646.6008 |
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| SMILES | COC(=O)C1[C@@H](C(C(=O)OC(=[OH+])C2=C(C)N=C(C)C([C@H]2c2cccc(c2)[N+]([O-])=O)=C([O-])OC)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |w:29.31,c:12,37,t:15,34| |
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| Structure | 
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