| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein kinase C beta type |
|---|
| Ligand | BDBM50282632 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_160470 (CHEMBL761766) |
|---|
| IC50 | 5.3±n/a nM |
|---|
| Citation |  Davis, PD; Hallam, TJ; Harris, W; Hill, CH; Lawton, G; Nixon, JS; Smith, JL; Vesey, DR; Wilkinson, SE Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain. Bioorg Med Chem Lett4:1303-1308 (1994) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein kinase C beta type |
|---|
| Name: | Protein kinase C beta type |
|---|
| Synonyms: | KPCB_RAT | PKC, rat brain | Pkcb | Prkcb | Prkcb1 | Protein Kinase C | Protein kinase C (PKC) | Protein kinase C beta |
|---|
| Type: | Enzyme Mixture |
|---|
| Mol. Mass.: | 76755.54 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | PKC from rat brain is known to contain predominately the conventional PKC isoforms, alpha, beta I, beta II, gamma. |
|---|
| Residue: | 671 |
|---|
| Sequence: | MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPEGSEGNEE
LRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF
SYTNPEFVINV
|
|
|
|---|
| BDBM50282632 |
|---|
| n/a |
|---|
| Name | BDBM50282632 |
|---|
| Synonyms: | 3-((3aR,10aR)-2-Methyl-2,3,3a,4,10,10a-hexahydro-1H-2,4a-diaza-cyclopenta[b]fluoren-9-yl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione; hydrochloride | CHEMBL538718 | Ro-32-0557 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H26N4O2 |
|---|
| Mol. Mass. | 450.5316 |
|---|
| SMILES | CN1C[C@@H]2Cc3c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c4ccccc4n3C[C@H]2C1 |r,t:7| |
|---|
| Structure | 
|
|---|
Search and Browse
