| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor B |
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| Ligand | BDBM50283551 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_36638 (CHEMBL652349) |
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| IC50 | 15±n/a nM |
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| Citation |  Huang, HC; Chamberlain, TS; Olins, GM; Corpus, VM; Chen, ST; McMahon, EG; Palomo, MA; Blaine, EH; Manning, RE Discovery of nonpeptide potent conformationally restricted angiotensin II receptor antagonists Bioorg Med Chem Lett4:2591-2596 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor B |
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| Name: | Type-1 angiotensin II receptor B |
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| Synonyms: | AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40929.44 |
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| Organism: | RAT |
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| Description: | Angiotensin II AT1B 0 RAT::P29089 |
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| Residue: | 359 |
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| Sequence: | MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
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| BDBM50283551 |
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| n/a |
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| Name | BDBM50283551 |
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| Synonyms: | 1-{(5S,8S)-3-Butyl-5-[2'-(2H-tetrazol-5-yl)-biphenyl-4-yl]-5,6,7,8-tetrahydro-imidazo[1,5-a]pyridin-8-yl}-pyrrolidine-2,5-dione | CHEMBL316392 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29N7O2 |
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| Mol. Mass. | 495.5756 |
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| SMILES | CCCCc1ncc2[C@H](CC[C@@H](c3ccc(cc3)-c3ccccc3-c3nnn[nH]3)n12)N1C(=O)CCC1=O |
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| Structure | 
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