| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50284448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_36632 (CHEMBL652343) |
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| IC50 | 21±n/a nM |
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| Citation |  Walsh, TF; Fitch, KJ; Chang, RS; Faust, KA; Chen, TB; Kivlighn, SD; Zingaro, GJ; Lotti, VJ; Siegl, PK; Patchett, AA; Greenlee, WJ α-Phenoxyphenylacetic acid derived angiotensin II antagonists with low nanomolar AT1/AT2 receptor subtype affinity (Part II) Bioorg Med Chem Lett5:1151-1154 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41009.15 |
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| Organism: | RABBIT |
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| Description: | ANGIOTENSIN AT1 AGTR1 RABBIT::P34976 |
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| Residue: | 359 |
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| Sequence: | MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
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| BDBM50284448 |
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| n/a |
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| Name | BDBM50284448 |
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| Synonyms: | CHEMBL280290 | [2,6-Dichloro-4-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenoxy]-phenyl-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23Cl2N3O3 |
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| Mol. Mass. | 484.374 |
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| SMILES | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(O)=O)c2ccccc2)c(Cl)c1 |
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| Structure | 
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