| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM914 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_157712 (CHEMBL763386) |
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| Ki | 100±n/a nM |
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| Citation |  Ahmad, S; Ashfaq, A; Alam, M; Bisacchi, GS; Chen, P; Cheng, PT; Greytok, JA; Hermsmeier, MA; Lin, PF; Lis, KA; Merchant, Z; Mitt, T; Skoog, M; Spergel, SH; Tino, JA; Vite, GD; Colonno, RJ; Zahler, R; Barrish, JC α-hydroxyamide derived aminodiols as potent inhibitors of hiv protease Bioorg Med Chem Lett5:1729-1734 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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| BDBM914 |
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| n/a |
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| Name | BDBM914 |
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| Synonyms: | Aminodiol deriv. 9a | BMS-186318 analog 1 | [(S,R)-3-[[(R,S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl]amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic Acid, 1,1-Dimethylethyl Ester | tert-butyl N-[(2S,3R)-4-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-4-phenylbutyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C30H45N3O6 |
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| Mol. Mass. | 543.6948 |
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| SMILES | CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C |r| |
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| Structure | 
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