Reaction Details |
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Target | GTPase HRas |
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Ligand | BDBM50287960 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_143166 |
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IC50 | 1000±n/a nM |
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Citation | Wolin, R; Wang, D; Kelly, J; Afonso, A; James, L; Kirschmeier, P; McPhail, AT Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras Bioorg Med Chem Lett6:195-200 (1996) Article |
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More Info.: | Get all data from this article, Assay Method |
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GTPase HRas |
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Name: | GTPase HRas |
Synonyms: | GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | RASH_HUMAN | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras |
Type: | Other Protein Type |
Mol. Mass.: | 21293.37 |
Organism: | Homo sapiens (Human) |
Description: | P01112 |
Residue: | 189 |
Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
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BDBM50287960 |
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n/a |
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Name | BDBM50287960 |
Synonyms: | 1-[(2R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(2-nitro-benzenesulfonyl)-morpholin-2-yl]-4-chloro-6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline | CHEMBL304462 |
Type | Small organic molecule |
Emp. Form. | C29H36ClN5O5SSi |
Mol. Mass. | 630.23 |
SMILES | COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@@H](CO[Si](C)(C)C(C)(C)C)O1)Sc1ccccc1[N+]([O-])=O |
Structure |
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