| Reaction Details |
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 | Report a problem with these data |
| Target | Complement C1r subcomponent |
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| Ligand | BDBM50289007 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_40170 (CHEMBL655965) |
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| IC50 | 700±n/a nM |
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| Citation |  Gilmore, JL; Hays, SJ; Caprathe, BW; Lee, C; Emmerling, MR; Michael, W; Jaen, JC Synthesis and evaluation of 2-aryl-4H-3,1-benzoxazin-4-ones as C1r serine protease inhibitors Bioorg Med Chem Lett6:679-682 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Complement C1r subcomponent |
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| Name: | Complement C1r subcomponent |
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| Synonyms: | C1R | C1R_HUMAN | Complement C1r | Complement C1r subcomponent |
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| Type: | Enzyme |
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| Mol. Mass.: | 80113.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00736 |
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| Residue: | 705 |
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| Sequence: | MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVF
QQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDF
SNEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGY
ELQEDTHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPF
DIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKL
RYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQD
DGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSR
ESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVF
TNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRV
SVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVME
EKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAV
RDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED
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| BDBM50289007 |
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| n/a |
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| Name | BDBM50289007 |
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| Synonyms: | 2-(2-Iodo-phenyl)-naphtho[2,3-d][1,3]oxazin-4-one | CHEMBL158926 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H10INO2 |
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| Mol. Mass. | 399.182 |
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| SMILES | Ic1ccccc1-c1nc2cc3ccccc3cc2c(=O)o1 |
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| Structure | 
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