Reaction Details |
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Target | Caspase-1 |
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Ligand | BDBM50289409 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_90985 |
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Ki | 14±n/a nM |
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Citation | Semple, G; Ashworth, DM; Baker, GR; Batt, AR; Baxter, AJ; Benzies, DW; Elliot, LH; Evans, D; Franklin, RJ; Hudson, P; Jenkins, PD; Pitt, GR; Rooker, DP; Sheppard, A; Szelke, M; Yamamoto, S; Isomura, Y PYRIDONE-BASED PEPTIDOMIMETIC INHIBITORS OF INTERLEUKIN-1β-CONVERTING ENZYME (ICE) Bioorg Med Chem Lett7:1337-1342 (1997) Article |
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More Info.: | Get all data from this article, Assay Method |
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Caspase-1 |
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Name: | Caspase-1 |
Synonyms: | CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme |
Type: | Enzyme |
Mol. Mass.: | 45154.13 |
Organism: | Homo sapiens (Human) |
Description: | P29466 |
Residue: | 404 |
Sequence: | MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
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BDBM50289409 |
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n/a |
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Name | BDBM50289409 |
Synonyms: | (S)-3-(2-{3-[(Naphthalene-2-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-propionylamino)-4-oxo-5-phenoxy-pentanoic acid | CHEMBL284415 |
Type | Small organic molecule |
Emp. Form. | C30H27N3O7 |
Mol. Mass. | 541.5513 |
SMILES | CC(C(=O)N[C@@H](CC(O)=O)C(=O)COc1ccccc1)n1cccc(NC(=O)c2ccc3ccccc3c2)c1=O |
Structure |
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