Reaction Details |
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Target | Prothrombin |
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Ligand | BDBM50289558 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_208130 |
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IC50 | 141±n/a nM |
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Citation | Tamura, SY; Semple, JE; Reiner, JE; Goldman, EA; Brunck, TK; Lim-Wilby, MS; Carpenter, SH; Rote, WE; Oldeshulte, GL; Richard, BM; Nutt, RF; Ripka, WC Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates Bioorg Med Chem Lett7:1543-1548 (1997) Article |
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More Info.: | Get all data from this article, Assay Method |
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Prothrombin |
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Name: | Prothrombin |
Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
Type: | Protein |
Mol. Mass.: | 70029.57 |
Organism: | Homo sapiens (Human) |
Description: | P00734 |
Residue: | 622 |
Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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BDBM50289558 |
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n/a |
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Name | BDBM50289558 |
Synonyms: | CHEMBL40071 | N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-(3-methyl-2,6-dioxo-5-phenylmethanesulfonylamino-3,6-dihydro-2H-pyrimidin-1-yl)-acetamide |
Type | Small organic molecule |
Emp. Form. | C20H27N7O6S |
Mol. Mass. | 493.537 |
SMILES | Cn1cc(NS(=O)(=O)Cc2ccccc2)c(=O)n(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)c1=O |
Structure |
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