| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease 1 |
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| Ligand | BDBM50076074 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_212714 |
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| IC50 | 26±n/a nM |
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| Citation |  Tamura, SY; Semple, JE; Reiner, JE; Goldman, EA; Brunck, TK; Lim-Wilby, MS; Carpenter, SH; Rote, WE; Oldeshulte, GL; Richard, BM; Nutt, RF; Ripka, WC Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates Bioorg Med Chem Lett7:1543-1548 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease 1 |
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| Name: | Serine protease 1 |
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| Synonyms: | Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 26557.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07477 |
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| Residue: | 247 |
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| Sequence: | MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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| BDBM50076074 |
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| n/a |
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| Name | BDBM50076074 |
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| Synonyms: | 1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro-5-pyridinyl]-2-(3-benzylsulfonamido-2-oxo-1,2-dihydro-1-pyridinyl)acetamide | CHEMBL41267 | N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-(2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N6O5S |
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| Mol. Mass. | 462.523 |
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| SMILES | NC(=N)N1CCC[C@H](NC(=O)Cn2cccc(NS(=O)(=O)Cc3ccccc3)c2=O)C1O |
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| Structure | 
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