| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-1 adrenergic receptor |
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| Ligand | BDBM50002133 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_37403 |
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| Ki | 1130±n/a nM |
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| Citation |  Sher, PM; Mathur, A; Fisher, LG; Wu, G; Skwish, S; Michel, IM; Seiler, SM; Dickinson, KE Carboxyl-promoted enhancement of selectivity for the β3 adrenergic receptor. Negative charge of the sulfonic acid BMS-187413 introduces-β3 binding selectivity Bioorg Med Chem Lett7:1583-1588 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-1 adrenergic receptor |
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| Name: | Beta-1 adrenergic receptor |
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| Synonyms: | ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 51338.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08588 |
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| Residue: | 477 |
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| Sequence: | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
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| BDBM50002133 |
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| n/a |
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| Name | BDBM50002133 |
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| Synonyms: | (+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydroxyethylamino)propyl)phenoxy)acetic acid | (4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxy)-acetic acid | (4-{2-[(R)-2-((R)-3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxy)-acetic acid | (4-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxy)-acetic acid | (BRL 37,344)(4-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxy)-acetic acid | (R*, R*) (4-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxy)-acetic acid | 2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydroxyethylamino)propyl)phenoxy)acetic acid | BRL-37344 | CHEMBL284782 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22ClNO4 |
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| Mol. Mass. | 363.835 |
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| SMILES | C[C@H](Cc1ccc(OCC(O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1 |
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| Structure | 
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