| Reaction Details |
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 | Report a problem with these data |
| Target | Cytosolic phospholipase A2 |
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| Ligand | BDBM50292834 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_493930 (CHEMBL947342) |
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| IC50 | 240±n/a nM |
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| Citation |  Chen, L; Wang, W; Lee, KL; Shen, MW; Murphy, EA; Zhang, W; Xu, X; Tam, S; Nickerson-Nutter, C; Goodwin, DG; Clark, JD; McKew, JC Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors. J Med Chem52:1156-71 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytosolic phospholipase A2 |
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| Name: | Cytosolic phospholipase A2 |
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| Synonyms: | CPLA2 | Lysophospholipase | PA24A_HUMAN | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 | Phospholipase A2 group IVA |
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| Type: | Protein |
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| Mol. Mass.: | 85219.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47712 |
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| Residue: | 749 |
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| Sequence: | MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETE
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
QNPSRCSVSLSNVEARRFFNKEFLSKPKA
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| BDBM50292834 |
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| n/a |
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| Name | BDBM50292834 |
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| Synonyms: | 4-[2-(1-Benzhydryl-5-chloro-2-{2-[({[(3,4-dichlorophenyl)thio]methyl}sulfonyl)amino]ethyl}-1H-indol-3-yl)ethoxy]benzoic Acid | CHEMBL449829 |
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| Type | Small organic molecule |
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| Emp. Form. | C39H33Cl3N2O5S2 |
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| Mol. Mass. | 780.179 |
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| SMILES | OC(=O)c1ccc(OCCc2c(CCNS(=O)(=O)CSc3ccc(Cl)c(Cl)c3)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1 |
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| Structure | 
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