| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 5 |
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| Ligand | BDBM50295874 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_578764 (CHEMBL1052337) |
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| IC50 | 11000±n/a nM |
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| Citation |  Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins. Bioorg Med Chem17:4420-4 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 5 |
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| Name: | Cyclin-dependent kinase 5 |
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| Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33308.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 292 |
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| Sequence: | MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH
KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR
NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS
TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP
MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
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| BDBM50295874 |
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| n/a |
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| Name | BDBM50295874 |
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| Synonyms: | 4-(1H-indol-3-yl)-5-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine | CHEMBL550658 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H13F3N4 |
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| Mol. Mass. | 354.3285 |
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| SMILES | Nc1ncc(-c2ccc(cc2)C(F)(F)F)c(n1)-c1c[nH]c2ccccc12 |
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| Structure | 
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