| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50296265 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_579862 (CHEMBL1063248) |
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| IC50 | 11879±n/a nM |
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| Citation |  Shi, Y; Zhang, J; Shi, M; O'Connor, SP; Bisaha, SN; Li, C; Sitkoff, D; Pudzianowski, AT; Chong, S; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors. Bioorg Med Chem Lett19:4034-41 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50296265 |
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| n/a |
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| Name | BDBM50296265 |
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| Synonyms: | (S)-2-cyano-1-(2-methyl-1H-benzo[d]imidazol-5-yl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)guanidine | CHEMBL561575 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H28N8O2 |
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| Mol. Mass. | 436.5101 |
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| SMILES | Cc1nc2ccc(cc2[nH]1)N=C(NC#N)N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O |r,w:10.11| |
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| Structure | 
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