Reaction Details |
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Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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Ligand | BDBM50299525 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_591437 (CHEMBL1054557) |
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IC50 | 510±n/a nM |
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Citation | Dahl, R; Sergienko, EA; Su, Y; Mostofi, YS; Yang, L; Simao, AM; Narisawa, S; Brown, B; Mangravita-Novo, A; Vicchiarelli, M; Smith, LH; O'Neill, WC; Millán, JL; Cosford, ND Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). J Med Chem52:6919-25 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alkaline phosphatase, tissue-nonspecific isozyme |
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Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
Synonyms: | ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor |
Type: | PROTEIN |
Mol. Mass.: | 57306.17 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1448917 |
Residue: | 524 |
Sequence: | MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
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BDBM50299525 |
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n/a |
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Name | BDBM50299525 |
Synonyms: | 5-chloro-2-methoxy-4-methyl-N-(pyridin-3-yl)benzenesulfonamide | CHEMBL578154 | cid_6473097 |
Type | Small organic molecule |
Emp. Form. | C13H13ClN2O3S |
Mol. Mass. | 312.772 |
SMILES | COc1cc(C)c(Cl)cc1S(=O)(=O)Nc1cccnc1 |
Structure |
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