Reaction Details |
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Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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Ligand | BDBM50299523 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_591450 (CHEMBL1054570) |
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Ki | 340±n/a nM |
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Citation | Dahl, R; Sergienko, EA; Su, Y; Mostofi, YS; Yang, L; Simao, AM; Narisawa, S; Brown, B; Mangravita-Novo, A; Vicchiarelli, M; Smith, LH; O'Neill, WC; Millán, JL; Cosford, ND Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). J Med Chem52:6919-25 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alkaline phosphatase, tissue-nonspecific isozyme |
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Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
Synonyms: | ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor |
Type: | PROTEIN |
Mol. Mass.: | 57306.17 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1448917 |
Residue: | 524 |
Sequence: | MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
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BDBM50299523 |
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n/a |
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Name | BDBM50299523 |
Synonyms: | 2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide | CHEMBL567850 | cid_2931238 |
Type | Small organic molecule |
Emp. Form. | C17H16N2O4S |
Mol. Mass. | 344.385 |
SMILES | COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccccc2c1 |
Structure |
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