| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 3 |
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| Ligand | BDBM50229382 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_600877 (CHEMBL1042835) |
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| IC50 | 10±n/a nM |
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| Citation |  Du, X; Gustin, DJ; Chen, X; Duquette, J; McGee, LR; Wang, Z; Ebsworth, K; Henne, K; Lemon, B; Ma, J; Miao, S; Sabalan, E; Sullivan, TJ; Tonn, G; Collins, TL; Medina, JC Imidazo-pyrazine derivatives as potent CXCR3 antagonists. Bioorg Med Chem Lett19:5200-4 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 3 |
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| Name: | C-X-C chemokine receptor type 3 |
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| Synonyms: | AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40665.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 368 |
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| Sequence: | MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALY
SLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFG
SGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCL
LFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILA
VLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAK
SVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSET
SEASYSGL
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| BDBM50229382 |
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| n/a |
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| Name | BDBM50229382 |
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| Synonyms: | (R)-N-(1-(3-(4-cyanophenyl)imidazo[1,2-a]pyrimidin-2-yl)ethyl)-N-(2-(ethylsulfonyl)ethyl)-2-(4-fluoro-3-(trifluoromethyl)phenyl)acetamide | CHEMBL400736 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H25F4N5O3S |
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| Mol. Mass. | 587.588 |
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| SMILES | CCS(=O)(=O)CCN([C@H](C)c1nc2ncccn2c1-c1ccc(cc1)C#N)C(=O)Cc1ccc(F)c(c1)C(F)(F)F |
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| Structure | 
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