Reaction Details |
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Target | Histamine H1 receptor |
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Ligand | BDBM50301391 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_599955 (CHEMBL1048093) |
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Ki | 39±n/a nM |
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Citation | Aslanian, R; Piwinski, JJ; Zhu, X; Priestley, T; Sorota, S; Du, XY; Zhang, XS; McLeod, RL; West, RE; Williams, SM; Hey, JA Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs. Bioorg Med Chem Lett19:5043-7 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H1 receptor |
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Name: | Histamine H1 receptor |
Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 55808.72 |
Organism: | Homo sapiens (Human) |
Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
Residue: | 487 |
Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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BDBM50301391 |
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n/a |
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Name | BDBM50301391 |
Synonyms: | 1-[4-(4-methylphenyl)butyl]-alpha,alpha-diphenyl-4-piperdine-methanol | CHEMBL571389 |
Type | Small organic molecule |
Emp. Form. | C29H35NO |
Mol. Mass. | 413.5943 |
SMILES | Cc1ccc(CCCCN2CCC(CC2)C(O)(c2ccccc2)c2ccccc2)cc1 |
Structure |
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