| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prothrombin |
|---|
| Ligand | BDBM50301570 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_600518 (CHEMBL1049043) |
|---|
| IC50 | 3960±n/a nM |
|---|
| Citation |  Hanessian, S; Therrien, E; Zhang, J; Otterlo, W; Xue, Y; Gustafsson, D; Nilsson, I; Fjellström, O From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs. Bioorg Med Chem Lett19:5429-32 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prothrombin |
|---|
| Name: | Prothrombin |
|---|
| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 70029.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00734 |
|---|
| Residue: | 622 |
|---|
| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
|
|
|
|---|
| BDBM50301570 |
|---|
| n/a |
|---|
| Name | BDBM50301570 |
|---|
| Synonyms: | CHEMBL567031 | N-(4-carbamimidoylbenzyl)-2-(4-methyl-2-oxo-1-(phenylmethylsulfonamido)-1,2-dihydropyridin-3-yl)acetamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H25N5O4S |
|---|
| Mol. Mass. | 467.541 |
|---|
| SMILES | Cc1ccn(NS(=O)(=O)Cc2ccccc2)c(=O)c1CC(=O)NCc1ccc(cc1)C(N)=N |
|---|
| Structure | 
|
|---|
Search and Browse
