Reaction Details | |||
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Target | Neuropeptide Y receptor type 5 | ||
Ligand | BDBM50301653 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_600730 (CHEMBL1037442) | ||
IC50 | 2.2±n/a nM | ||
Citation | Takahashi, H; Haga, Y; Shibata, T; Nonoshita, K; Sakamoto, T; Moriya, M; Ohe, T; Chiba, M; Mitobe, Y; Kitazawa, H; Iwaasa, H; Ishihara, A; Ishii, Y; Kanatani, A; Fukami, T Identification of positron emission tomography ligands for NPY Y5 receptors in the brain. Bioorg Med Chem Lett19:5436-9 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Neuropeptide Y receptor type 5 | |||
Name: | Neuropeptide Y receptor type 5 | ||
Synonyms: | NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor | ||
Type: | Enzyme | ||
Mol. Mass.: | 50746.64 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15761 | ||
Residue: | 445 | ||
Sequence: |
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BDBM50301653 | |||
n/a | |||
Name | BDBM50301653 | ||
Synonyms: | CHEMBL583007 | trans-N-(5-(4-fluorophenyl)pyrimidin-2-yl)-3'-oxo-3'H-spiro[cyclohexane-1,1'-furo[3,4-c]pyridine]-4-carboxamide | ||
Type | Small organic molecule | ||
Emp. Form. | C23H19FN4O3 | ||
Mol. Mass. | 418.4204 | ||
SMILES | Fc1ccc(cc1)-c1cnc(NC(=O)[C@H]2CC[C@@]3(CC2)OC(=O)c2cnccc32)nc1 |r,wU:17.21,wD:14.14,(33,-12.26,;31.67,-11.49,;30.33,-12.27,;29,-11.5,;29,-9.96,;30.33,-9.18,;31.66,-9.95,;27.67,-9.19,;26.33,-9.96,;25,-9.19,;25.01,-7.65,;23.68,-6.88,;22.34,-7.65,;21.01,-6.88,;22.34,-9.19,;21.01,-9.97,;21.01,-11.51,;22.34,-12.27,;23.67,-11.51,;23.67,-9.97,;23.26,-13.52,;22.36,-14.78,;22.84,-16.24,;20.88,-14.31,;19.54,-15.08,;18.2,-14.31,;18.21,-12.76,;19.53,-11.99,;20.87,-12.76,;26.33,-6.88,;27.66,-7.64,)| | ||
Structure |