| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 8 |
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| Ligand | BDBM50301804 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_598187 (CHEMBL1045181) |
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| IC50 | >10000±n/a nM |
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| Citation |  Ito, S; Hirata, Y; Nagatomi, Y; Satoh, A; Suzuki, G; Kimura, T; Satow, A; Maehara, S; Hikichi, H; Hata, M; Ohta, H; Kawamoto, H Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: a potential treatment for psychotic disorders. Bioorg Med Chem Lett19:5310-3 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 8 |
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| Name: | Metabotropic glutamate receptor 8 |
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| Synonyms: | GPRC1H | GRM8 | GRM8_HUMAN | MGLUR8 | Metabotropic glutamate receptor 8 | metabotropic glutamate 8 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 101759.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | metabotropic glutamate 8 GRM8 HUMAN::O00222 |
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| Residue: | 908 |
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| Sequence: | MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN
KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF
VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC
FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTY
ISYSNHSI
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| BDBM50301804 |
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| n/a |
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| Name | BDBM50301804 |
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| Synonyms: | 5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl)-2-isopropylisoindolin-1-one | CHEMBL579062 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18F2N4O |
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| Mol. Mass. | 368.3799 |
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| SMILES | CC(C)N1Cc2cc(ccc2C1=O)-c1nnn(c1C)-c1ccc(F)cc1F |
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| Structure | 
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