Compile Data Set for Download or QSAR

Found 112 hits with Last Name = 'satow' and Initial = 'a'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Mus musculus)	BDBM50273899 (CHEMBL456823 | tert-Butyl-4-[1-(2-fuluoropyridine-...) Show SMILES Cc1c(nnn1-c1ncccc1F)C1=CCN(CC1)C(=O)OC(C)(C)C |t:15| Show InChI InChI=1S/C18H22FN5O2/c1-12-15(21-22-24(12)16-14(19)6-5-9-20-16)13-7-10-23(11-8-13)17(25)26-18(2,3)4/h5-7,9H,8,10-11H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301542 (4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...) Show SMILES CNc1cc(ncn1)-c1csc(n1)N(C)C(=O)c1ccc(F)cc1 Show InChI InChI=1S/C16H14FN5OS/c1-18-14-7-12(19-9-20-14)13-8-24-16(21-13)22(2)15(23)10-3-5-11(17)6-4-10/h3-9H,1-2H3,(H,18,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301541 (CHEMBL577729 | N-(4-(6-aminopyrimidin-4-yl)thiazol...) Show SMILES CN(C(=O)c1ccc(F)cc1)c1nc(cs1)-c1cc(N)ncn1 Show InChI InChI=1S/C15H12FN5OS/c1-21(14(22)9-2-4-10(16)5-3-9)15-20-12(7-23-15)11-6-13(17)19-8-18-11/h2-8H,1H3,(H2,17,18,19)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50273898 (CHEMBL452618 | tert-Butyl-4-[1-(2-fuluoropyridine-...) Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cn(nn1)-c1ncccc1F |c:10| Show InChI InChI=1S/C17H20FN5O2/c1-17(2,3)25-16(24)22-9-6-12(7-10-22)14-11-23(21-20-14)15-13(18)5-4-8-19-15/h4-6,8,11H,7,9-10H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301816 (2-cyclopropyl-5-(5-methyl-1-(pyridin-3-yl)-1H-1,2,...) Show SMILES Cc1c(nnn1-c1cccnc1)-c1ccc2C(=O)C(Cc2c1)C1CC1 Show InChI InChI=1S/C20H18N4O/c1-12-19(22-23-24(12)16-3-2-8-21-11-16)14-6-7-17-15(9-14)10-18(20(17)25)13-4-5-13/h2-3,6-9,11,13,18H,4-5,10H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...				Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Mus musculus)	BDBM50273942 (4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...) Show SMILES CC(C)N(C)C(=O)N1CCC(=CC1)c1nnn(c1C)-c1cccnc1F |c:10| Show InChI InChI=1S/C18H23FN6O/c1-12(2)23(4)18(26)24-10-7-14(8-11-24)16-13(3)25(22-21-16)15-6-5-9-20-17(15)19/h5-7,9,12H,8,10-11H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Mus musculus)	BDBM50273941 (CHEMBL456196 | iso-Propyl-4-[1-(2-fuluoropyridine-...) Show SMILES CC(C)OC(=O)N1CCC(=CC1)c1nnn(c1C)-c1cccnc1F |c:9| Show InChI InChI=1S/C17H20FN5O2/c1-11(2)25-17(24)22-9-6-13(7-10-22)15-12(3)23(21-20-15)14-5-4-8-19-16(14)18/h4-6,8,11H,7,9-10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301821 (2-ethyl-5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,...) Show SMILES CCN1Cc2cc(ccc2C1=O)-c1nnn(c1C)-c1cccnc1F Show InChI InChI=1S/C18H16FN5O/c1-3-23-10-13-9-12(6-7-14(13)18(23)25)16-11(2)24(22-21-16)15-5-4-8-20-17(15)19/h4-9H,3,10H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...				Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301824 (2-cyclopropyl-5-(1-(2-fluoropyridin-3-yl)-5-methyl...) Show SMILES Cc1c(nnn1-c1cccnc1F)-c1ccc2C(=O)N(Cc2c1)C1CC1 Show InChI InChI=1S/C19H16FN5O/c1-11-17(22-23-25(11)16-3-2-8-21-18(16)20)12-4-7-15-13(9-12)10-24(19(15)26)14-5-6-14/h2-4,7-9,14H,5-6,10H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...				Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301822 (5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...) Show SMILES CCCN1Cc2cc(ccc2C1=O)-c1nnn(c1C)-c1cccnc1F Show InChI InChI=1S/C19H18FN5O/c1-3-9-24-11-14-10-13(6-7-15(14)19(24)26)17-12(2)25(23-22-17)16-5-4-8-21-18(16)20/h4-8,10H,3,9,11H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...				Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50301804 (5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazo...) Show SMILES CC(C)N1Cc2cc(ccc2C1=O)-c1nnn(c1C)-c1ccc(F)cc1F Show InChI InChI=1S/C20H18F2N4O/c1-11(2)25-10-14-8-13(4-6-16(14)20(25)27)19-12(3)26(24-23-19)18-7-5-15(21)9-17(18)22/h4-9,11H,10H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FLIP...				Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301543 (CHEMBL566374 | N-(4-(6-(ethylamino)pyrimidin-4-yl)...) Show SMILES CCNc1cc(ncn1)-c1csc(n1)N(C)C(=O)c1ccc(F)cc1 Show InChI InChI=1S/C17H16FN5OS/c1-3-19-15-8-13(20-10-21-15)14-9-25-17(22-14)23(2)16(24)11-4-6-12(18)7-5-11/h4-10H,3H2,1-2H3,(H,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301818 (6-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-triazol-4-yl...) Show SMILES Cc1c(nnn1-c1cccnc1)-c1ccc2ncccc2c1 Show InChI InChI=1S/C17H13N5/c1-12-17(20-21-22(12)15-5-3-8-18-11-15)14-6-7-16-13(10-14)4-2-9-19-16/h2-11H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...				Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301520 (4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)th...) Show SMILES CC(C)Nc1cc(ncn1)-c1csc(n1)N(C)C(=O)c1ccc(F)cc1 Show InChI InChI=1S/C18H18FN5OS/c1-11(2)22-16-8-14(20-10-21-16)15-9-26-18(23-15)24(3)17(25)12-4-6-13(19)7-5-12/h4-11H,1-3H3,(H,20,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301823 (5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...) Show SMILES CC(C)N1Cc2cc(ccc2C1=O)-c1nnn(c1C)-c1cccnc1F Show InChI InChI=1S/C19H18FN5O/c1-11(2)24-10-14-9-13(6-7-15(14)19(24)26)17-12(3)25(23-22-17)16-5-4-8-21-18(16)20/h4-9,11H,10H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...				Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50273942 (4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...) Show SMILES CC(C)N(C)C(=O)N1CCC(=CC1)c1nnn(c1C)-c1cccnc1F |c:10| Show InChI InChI=1S/C18H23FN6O/c1-12(2)23(4)18(26)24-10-7-14(8-11-24)16-13(3)25(22-21-16)15-6-5-9-20-17(15)19/h5-7,9,12H,8,10-11H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...				Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50273942 (4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...) Show SMILES CC(C)N(C)C(=O)N1CCC(=CC1)c1nnn(c1C)-c1cccnc1F |c:10| Show InChI InChI=1S/C18H23FN6O/c1-12(2)23(4)18(26)24-10-7-14(8-11-24)16-13(3)25(22-21-16)15-6-5-9-20-17(15)19/h5-7,9,12H,8,10-11H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301532 (4-fluoro-N-methyl-N-(4-(pyridin-2-yl)thiazol-2-yl)...) Show SMILES CN(C(=O)c1ccc(F)cc1)c1nc(cs1)-c1ccccn1 Show InChI InChI=1S/C16H12FN3OS/c1-20(15(21)11-5-7-12(17)8-6-11)16-19-14(10-22-16)13-4-2-3-9-18-13/h2-10H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50273829 (CHEMBL461673 | tert-Butyl-4-[1-(2-fluorophenyl)-1H...) Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cn(nn1)-c1ccccc1F |c:10| Show InChI InChI=1S/C18H21FN4O2/c1-18(2,3)25-17(24)22-10-8-13(9-11-22)15-12-23(21-20-15)16-7-5-4-6-14(16)19/h4-8,12H,9-11H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50273899 (CHEMBL456823 | tert-Butyl-4-[1-(2-fuluoropyridine-...) Show SMILES Cc1c(nnn1-c1ncccc1F)C1=CCN(CC1)C(=O)OC(C)(C)C |t:15| Show InChI InChI=1S/C18H22FN5O2/c1-12-15(21-22-24(12)16-14(19)6-5-9-20-16)13-7-10-23(11-8-13)17(25)26-18(2,3)4/h5-7,9H,8,10-11H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50273941 (CHEMBL456196 | iso-Propyl-4-[1-(2-fuluoropyridine-...) Show SMILES CC(C)OC(=O)N1CCC(=CC1)c1nnn(c1C)-c1cccnc1F |c:9| Show InChI InChI=1S/C17H20FN5O2/c1-11(2)25-17(24)22-9-6-13(7-10-22)15-12(3)23(21-20-15)14-5-4-8-19-16(14)18/h4-6,8,11H,7,9-10H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50273828 (CHEMBL511355 | tert-Butyl-4-(1-phenyl-1H-1,2,3-tri...) Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cn(nn1)-c1ccccc1 |c:10| Show InChI InChI=1S/C18H22N4O2/c1-18(2,3)24-17(23)21-11-9-14(10-12-21)16-13-22(20-19-16)15-7-5-4-6-8-15/h4-9,13H,10-12H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.80	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301534 (4-fluoro-N-methyl-N-(4-(pyrimidin-4-yl)thiazol-2-y...) Show SMILES CN(C(=O)c1ccc(F)cc1)c1nc(cs1)-c1ccncn1 Show InChI InChI=1S/C15H11FN4OS/c1-20(14(21)10-2-4-11(16)5-3-10)15-19-13(8-22-15)12-6-7-17-9-18-12/h2-9H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50273864 (CHEMBL511352 | tert-Butyl-4-[1-(2-methylphenyl)-1H...) Show SMILES Cc1ccccc1-n1cc(nn1)C1=CCN(CC1)C(=O)OC(C)(C)C |t:14| Show InChI InChI=1S/C19H24N4O2/c1-14-7-5-6-8-17(14)23-13-16(20-21-23)15-9-11-22(12-10-15)18(24)25-19(2,3)4/h5-9,13H,10-12H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301815 (2,2-dimethyl-5-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3...) Show SMILES Cc1c(nnn1-c1cccnc1)-c1ccc2C(=O)C(C)(C)Cc2c1 Show InChI InChI=1S/C19H18N4O/c1-12-17(21-22-23(12)15-5-4-8-20-11-15)13-6-7-16-14(9-13)10-19(2,3)18(16)24/h4-9,11H,10H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...				Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Mus musculus)	BDBM50273898 (CHEMBL452618 | tert-Butyl-4-[1-(2-fuluoropyridine-...) Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cn(nn1)-c1ncccc1F |c:10| Show InChI InChI=1S/C17H20FN5O2/c1-17(2,3)25-16(24)22-9-6-12(7-10-22)14-11-23(21-20-14)15-13(18)5-4-8-19-15/h4-6,8,11H,7,9-10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50273863 (CHEMBL460827 | tert-Butyl-4-[1-(4-fuluorophenyl)-1...) Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cn(nn1)-c1ccc(F)cc1 |c:10| Show InChI InChI=1S/C18H21FN4O2/c1-18(2,3)25-17(24)22-10-8-13(9-11-22)16-12-23(21-20-16)15-6-4-14(19)5-7-15/h4-8,12H,9-11H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Mus musculus)	BDBM50273829 (CHEMBL461673 | tert-Butyl-4-[1-(2-fluorophenyl)-1H...) Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cn(nn1)-c1ccccc1F |c:10| Show InChI InChI=1S/C18H21FN4O2/c1-18(2,3)25-17(24)22-10-8-13(9-11-22)15-12-23(21-20-15)16-7-5-4-6-14(16)19/h4-8,12H,9-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50273830 (CHEMBL460391 | tert-Butyl-4-[1-(3-fuluorophenyl)-1...) Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cn(nn1)-c1cccc(F)c1 |c:10| Show InChI InChI=1S/C18H21FN4O2/c1-18(2,3)25-17(24)22-9-7-13(8-10-22)16-12-23(21-20-16)15-6-4-5-14(19)11-15/h4-7,11-12H,8-10H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301537 (CHEMBL567668 | N-ethyl-4-fluoro-N-(4-(pyridin-2-yl...) Show SMILES CCN(C(=O)c1ccc(F)cc1)c1nc(cs1)-c1ccccn1 Show InChI InChI=1S/C17H14FN3OS/c1-2-21(16(22)12-6-8-13(18)9-7-12)17-20-15(11-23-17)14-5-3-4-10-19-14/h3-11H,2H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301807 (CHEMBL568648 | cyclopropyl(4-(5-methyl-1-(pyridin-...) Show SMILES Cc1c(nnn1-c1cccnc1)-c1ccc(cc1)C(=O)C1CC1 Show InChI InChI=1S/C18H16N4O/c1-12-17(20-21-22(12)16-3-2-10-19-11-16)13-4-6-14(7-5-13)18(23)15-8-9-15/h2-7,10-11,15H,8-9H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...				Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Mus musculus)	BDBM50273828 (CHEMBL511355 | tert-Butyl-4-(1-phenyl-1H-1,2,3-tri...) Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cn(nn1)-c1ccccc1 |c:10| Show InChI InChI=1S/C18H22N4O2/c1-18(2,3)24-17(23)21-11-9-14(10-12-21)16-13-22(20-19-16)15-7-5-4-6-8-15/h4-9,13H,10-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Mus musculus)	BDBM50273863 (CHEMBL460827 | tert-Butyl-4-[1-(4-fuluorophenyl)-1...) Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cn(nn1)-c1ccc(F)cc1 |c:10| Show InChI InChI=1S/C18H21FN4O2/c1-18(2,3)25-17(24)22-10-8-13(9-11-22)16-12-23(21-20-16)15-6-4-14(19)5-7-15/h4-8,12H,9-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301809 (CHEMBL568449 | isopropyl 4-(5-methyl-1-(pyridin-3-...) Show SMILES CC(C)OC(=O)c1ccc(cc1)-c1nnn(c1C)-c1cccnc1 Show InChI InChI=1S/C18H18N4O2/c1-12(2)24-18(23)15-8-6-14(7-9-15)17-13(3)22(21-20-17)16-5-4-10-19-11-16/h4-12H,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...				Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50273940 (CHEMBL457026 | iso-Propyl-4-[1-(2-fuluoropyridine-...) Show SMILES CC(C)OC(=O)N1CCC(=CC1)c1cn(nn1)-c1cccnc1F |c:9| Show InChI InChI=1S/C16H18FN5O2/c1-11(2)24-16(23)21-8-5-12(6-9-21)13-10-22(20-19-13)14-4-3-7-18-15(14)17/h3-5,7,10-11H,6,8-9H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Mus musculus)	BDBM50273830 (CHEMBL460391 | tert-Butyl-4-[1-(3-fuluorophenyl)-1...) Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cn(nn1)-c1cccc(F)c1 |c:10| Show InChI InChI=1S/C18H21FN4O2/c1-18(2,3)25-17(24)22-9-7-13(8-10-22)16-12-23(21-20-16)15-6-4-5-14(19)11-15/h4-7,11-12H,8-10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50273941 (CHEMBL456196 | iso-Propyl-4-[1-(2-fuluoropyridine-...) Show SMILES CC(C)OC(=O)N1CCC(=CC1)c1nnn(c1C)-c1cccnc1F |c:9| Show InChI InChI=1S/C17H20FN5O2/c1-11(2)25-17(24)22-9-6-13(7-10-22)15-12(3)23(21-20-15)14-5-4-8-19-16(14)18/h4-6,8,11H,7,9-10H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR5 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301523 (4-fluoro-N-methyl-N-(4-(pyridin-4-yl)thiazol-2-yl)...) Show SMILES CN(C(=O)c1ccc(F)cc1)c1nc(cs1)-c1ccncc1 Show InChI InChI=1S/C16H12FN3OS/c1-20(15(21)12-2-4-13(17)5-3-12)16-19-14(10-22-16)11-6-8-18-9-7-11/h2-10H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50273895 (CHEMBL457872 | tert-Butyl-4-[1-pyridin-2-yl-1H-1,2...) Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cn(nn1)-c1ccccn1 |c:10| Show InChI InChI=1S/C17H21N5O2/c1-17(2,3)24-16(23)21-10-7-13(8-11-21)14-12-22(20-19-14)15-6-4-5-9-18-15/h4-7,9,12H,8,10-11H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301533 (4-fluoro-N-methyl-N-(4-(pyrazin-2-yl)thiazol-2-yl)...) Show SMILES CN(C(=O)c1ccc(F)cc1)c1nc(cs1)-c1cnccn1 Show InChI InChI=1S/C15H11FN4OS/c1-20(14(21)10-2-4-11(16)5-3-10)15-19-13(9-22-15)12-8-17-6-7-18-12/h2-9H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50273896 (CHEMBL453249 | tert-Butyl-4-[1-pyridin-3-yl-1 H-1,...) Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cn(nn1)-c1cccnc1 |c:10| Show InChI InChI=1S/C17H21N5O2/c1-17(2,3)24-16(23)21-9-6-13(7-10-21)15-12-22(20-19-15)14-5-4-8-18-11-14/h4-6,8,11-12H,7,9-10H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50273866 (CHEMBL461034 | N-(tert-Butyl)-4-[1-(2-fluorophenyl...) Show SMILES CC(C)(C)NC(=O)N1CCC(=CC1)c1cn(nn1)-c1ccccc1F |c:10| Show InChI InChI=1S/C18H22FN5O/c1-18(2,3)20-17(25)23-10-8-13(9-11-23)15-12-24(22-21-15)16-7-5-4-6-14(16)19/h4-8,12H,9-11H2,1-3H3,(H,20,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Mus musculus)	BDBM50273864 (CHEMBL511352 | tert-Butyl-4-[1-(2-methylphenyl)-1H...) Show SMILES Cc1ccccc1-n1cc(nn1)C1=CCN(CC1)C(=O)OC(C)(C)C |t:14| Show InChI InChI=1S/C19H24N4O2/c1-14-7-5-6-8-17(14)23-13-16(20-21-23)15-9-11-22(12-10-15)18(24)25-19(2,3)4/h5-9,13H,10-12H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay				Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301522 (4-chloro-N-methyl-N-(4-(pyridin-4-yl)thiazol-2-yl)...) Show SMILES CN(C(=O)c1ccc(Cl)cc1)c1nc(cs1)-c1ccncc1 Show InChI InChI=1S/C16H12ClN3OS/c1-20(15(21)12-2-4-13(17)5-3-12)16-19-14(10-22-16)11-6-8-18-9-7-11/h2-10H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301814 (5-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-triazol-4-yl...) Show SMILES Cc1c(nnn1-c1cccnc1)-c1ccc2C(=O)CCc2c1 Show InChI InChI=1S/C17H14N4O/c1-11-17(19-20-21(11)14-3-2-8-18-10-14)13-4-6-15-12(9-13)5-7-16(15)22/h2-4,6,8-10H,5,7H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...				Bioorg Med Chem Lett 19: 5310-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.145 BindingDB Entry DOI: 10.7270/Q26H4HGN
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301544 (4-fluoro-N-(4-(6-(isopropyl(methyl)amino)pyrimidin...) Show SMILES CC(C)N(C)c1cc(ncn1)-c1csc(n1)N(C)C(=O)c1ccc(F)cc1 Show InChI InChI=1S/C19H20FN5OS/c1-12(2)24(3)17-9-15(21-11-22-17)16-10-27-19(23-16)25(4)18(26)13-5-7-14(20)8-6-13/h5-12H,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301527 (CHEMBL576121 | N-methyl-N-(4-(pyridin-4-yl)thiazol...) Show SMILES CN(C(=O)c1ccccc1)c1nc(cs1)-c1ccncc1 Show InChI InChI=1S/C16H13N3OS/c1-19(15(20)13-5-3-2-4-6-13)16-18-14(11-21-16)12-7-9-17-10-8-12/h2-11H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301538 (4-fluoro-N-propyl-N-(4-(pyridin-2-yl)thiazol-2-yl)...) Show SMILES CCCN(C(=O)c1ccc(F)cc1)c1nc(cs1)-c1ccccn1 Show InChI InChI=1S/C18H16FN3OS/c1-2-11-22(17(23)13-6-8-14(19)9-7-13)18-21-16(12-24-18)15-5-3-4-10-20-15/h3-10,12H,2,11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301524 (CHEMBL579225 | N,4-dimethyl-N-(4-(pyridin-4-yl)thi...) Show SMILES CN(C(=O)c1ccc(C)cc1)c1nc(cs1)-c1ccncc1 Show InChI InChI=1S/C17H15N3OS/c1-12-3-5-14(6-4-12)16(21)20(2)17-19-15(11-22-17)13-7-9-18-10-8-13/h3-11H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50301528 (3-fluoro-N-methyl-N-(4-(pyridin-4-yl)thiazol-2-yl)...) Show SMILES CN(C(=O)c1cccc(F)c1)c1nc(cs1)-c1ccncc1 Show InChI InChI=1S/C16H12FN3OS/c1-20(15(21)12-3-2-4-13(17)9-12)16-19-14(10-22-16)11-5-7-18-8-6-11/h2-10H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay				Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT
					More data for this Ligand-Target Pair

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