| Reaction Details |
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 | Report a problem with these data |
| Target | Sonic hedgehog protein |
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| Ligand | BDBM50302139 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_598862 (CHEMBL1044694) |
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| IC50 | 12±n/a nM |
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| Citation |  Robarge, KD; Brunton, SA; Castanedo, GM; Cui, Y; Dina, MS; Goldsmith, R; Gould, SE; Guichert, O; Gunzner, JL; Halladay, J; Jia, W; Khojasteh, C; Koehler, MF; Kotkow, K; La, H; Lalonde, RL; Lau, K; Lee, L; Marshall, D; Marsters, JC; Murray, LJ; Qian, C; Rubin, LL; Salphati, L; Stanley, MS; Stibbard, JH; Sutherlin, DP; Ubhayaker, S; Wang, S; Wong, S; Xie, M GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg Med Chem Lett19:5576-81 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sonic hedgehog protein |
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| Name: | Sonic hedgehog protein |
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| Synonyms: | Hhg1 | SHH_MOUSE | Shh |
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| Type: | Protein |
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| Mol. Mass.: | 47784.50 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q62226 |
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| Residue: | 437 |
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| Sequence: | MLLLLARCFLVILASSLLVCPGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGAS
GRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPG
VKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKA
HIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDFL
TFLDRDEGAKKVFYVIETLEPRERLLLTAAHLLFVAPHNDSGPTPGPSALFASRVRPGQR
VYVVAERGGDRRLLPAAVHSVTLREEEAGAYAPLTAHGTILINRVLASCYAVIEEHSWAH
RAFAPFRLAHALLAALAPARTDGGGGGSIPAAQSATEARGAEPTAGIHWYSQLLYHIGTW
LLDSETMHPLGMAVKSS
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| BDBM50302139 |
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| n/a |
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| Name | BDBM50302139 |
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| Synonyms: | CHEMBL570273 | N-(3-(1H-benzo[d]imidazol-2-yl)-4-chlorophenyl)-2-methyl-6-(trifluoromethyl)nicotinamide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H14ClF3N4O |
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| Mol. Mass. | 430.81 |
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| SMILES | Cc1nc(ccc1C(=O)Nc1ccc(Cl)c(c1)-c1nc2ccccc2[nH]1)C(F)(F)F |
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| Structure | 
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