Reaction Details |
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Target | Protein kinase C eta type |
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Ligand | BDBM50302507 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_597638 (CHEMBL1039090) |
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IC50 | 330±n/a nM |
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Citation | Niu, C; Boschelli, DH; Tumey, LN; Bhagirath, N; Subrath, J; Shim, J; Wang, Y; Wu, B; Eid, C; Lee, J; Yang, X; Brennan, A; Chaudhary, D First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. Bioorg Med Chem Lett19:5829-32 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein kinase C eta type |
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Name: | Protein kinase C eta type |
Synonyms: | KPCL_HUMAN | PKC-L | PKCL | PRKCH | PRKCL | Protein Kinase C, eta | Protein kinase C, PKC; classical/novel | nPKC-eta |
Type: | Enzyme |
Mol. Mass.: | 77844.26 |
Organism: | Homo sapiens (Human) |
Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
Residue: | 683 |
Sequence: | MSSGTMKFNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTK
QKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFEG
WVDLEPEGKVFVVITLTGSFTEATLQRDRIFKHFTRKRQRAMRRRVHQINGHKFMATYLR
QPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIAEQRF
GINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAV
ELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRV
LGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF
CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDL
KLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAM
GVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSL
TQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDE
GHLPMINQDEFRNFSYVSPELQP
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BDBM50302507 |
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n/a |
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Name | BDBM50302507 |
Synonyms: | 4-(4-methyl-1H-indol-5-ylamino)-5-(3-(2-(4-methylpiperazin-1-yl)ethoxy)styryl)nicotinonitrile | CHEMBL567124 |
Type | Small organic molecule |
Emp. Form. | C30H32N6O |
Mol. Mass. | 492.6147 |
SMILES | CN1CCN(CCOc2cccc(\C=C\c3cncc(C#N)c3Nc3ccc4[nH]ccc4c3C)c2)CC1 |
Structure |
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