Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50303164 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_594896 (CHEMBL1038947) |
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Ki | 1.7±n/a nM |
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Citation | Bernotas, RC; Antane, SA; Lenicek, SE; Haydar, SN; Robichaud, AJ; Harrison, BL; Zhang, GM; Smith, D; Coupet, J; Schechter, LE 1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands. Bioorg Med Chem Lett19:6935-8 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50303164 |
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n/a |
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Name | BDBM50303164 |
Synonyms: | 1-(1-(2-(dimethylamino)ethyl)-3-(naphthalen-1-ylsulfonyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)ethanone | CHEMBL568935 |
Type | Small organic molecule |
Emp. Form. | C23H23N3O3S |
Mol. Mass. | 421.512 |
SMILES | CN(C)CCn1cc(c2nc(ccc12)C(C)=O)S(=O)(=O)c1cccc2ccccc12 |
Structure |
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