Ki Summary

Reaction Details

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Target

Mitogen-activated protein kinase 14

Ligand

BDBM50304013

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_595431 (CHEMBL1040072)

IC50

211±n/a nM

Citation

Koch, P; Jahns, H; Schattel, V; Goettert, M; Laufer, S Pyridinylquinoxalines and pyridinylpyridopyrazines as lead compounds for novel p38 alpha mitogen-activated protein kinase inhibitors. J Med Chem53:1128-37 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase 14

Name:

Mitogen-activated protein kinase 14

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

41286.76

Organism:

Homo sapiens (Human)

Description:

Q16539

Residue:

360

Sequence:

MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES

BDBM50304013

n/a

Name

BDBM50304013

Synonyms:

4-(4-(3-(4-Fluorophenyl)quinoxalin-2-yl)pyridin-2-ylamino)cyclohexanol | CHEMBL566841

Type

Small organic molecule

Emp. Form.

C25H23FN4O

Mol. Mass.

414.4747

SMILES

O[C@H]1CC[C@@H](CC1)Nc1cc(ccn1)-c1nc2ccccc2nc1-c1ccc(F)cc1 |r,wU:1.0,wD:4.7,(2.39,-45.47,;3.72,-44.7,;3.72,-43.16,;5.04,-42.39,;6.37,-43.15,;6.39,-44.69,;5.06,-45.47,;7.7,-42.38,;7.69,-40.84,;9.02,-40.06,;9.01,-38.53,;7.68,-37.76,;6.34,-38.53,;6.35,-40.07,;10.34,-37.75,;11.67,-38.51,;13,-37.75,;14.33,-38.52,;15.67,-37.75,;15.66,-36.2,;14.33,-35.43,;13,-36.21,;11.67,-35.44,;10.34,-36.2,;9,-35.44,;9,-33.89,;7.67,-33.12,;6.33,-33.89,;5,-33.13,;6.34,-35.44,;7.67,-36.2,)|

Structure