Reaction Details |
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Target | 5-hydroxytryptamine receptor 2C |
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Ligand | BDBM50304809 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_606257 (CHEMBL1069947) |
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Ki | 4±n/a nM |
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Citation | Liu, KK; Cornelius, P; Patterson, TA; Zeng, Y; Santucci, S; Tomlinson, E; Gibbons, C; Maurer, TS; Marala, R; Brown, J; Kong, JX; Lee, E; Werner, W; Wenzel, Z; Vage, C Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett20:266-71 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 2C |
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Name: | 5-hydroxytryptamine receptor 2C |
Synonyms: | 5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 51836.79 |
Organism: | Homo sapiens (Human) |
Description: | P28335 |
Residue: | 458 |
Sequence: | MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
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BDBM50304809 |
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n/a |
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Name | BDBM50304809 |
Synonyms: | 4-(3-chlorobenzyloxy)-2-(piperazin-1-yl)thieno[2,3-d]pyrimidine | CHEMBL595646 |
Type | Small organic molecule |
Emp. Form. | C17H17ClN4OS |
Mol. Mass. | 360.861 |
SMILES | Clc1cccc(COc2nc(nc3sccc23)N2CCNCC2)c1 |
Structure |
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