| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
|---|
| Ligand | BDBM50305758 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_604760 (CHEMBL1072554) |
|---|
| IC50 | 5±n/a nM |
|---|
| Citation |  Léger, S; Black, WC; Deschenes, D; Dolman, S; Falgueyret, JP; Gagnon, M; Guiral, S; Huang, Z; Guay, J; Leblanc, Y; Li, CS; Massé, F; Oballa, R; Zhang, L Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett20:499-502 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acyl-CoA desaturase 1 |
|---|
| Name: | Acyl-CoA desaturase 1 |
|---|
| Synonyms: | ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41485.97 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P07308 |
|---|
| Residue: | 358 |
|---|
| Sequence: | MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQD
EEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHR
LWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSH
VGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGET
FLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYH
HAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
|
|
|
|---|
| BDBM50305758 |
|---|
| n/a |
|---|
| Name | BDBM50305758 |
|---|
| Synonyms: | 3-(4-(2-bromophenoxy)piperidin-1-yl)-6-(1H-imidazol-1-yl)pyridazine | CHEMBL594916 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H18BrN5O |
|---|
| Mol. Mass. | 400.272 |
|---|
| SMILES | Brc1ccccc1OC1CCN(CC1)c1ccc(nn1)-n1ccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
