| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4 |
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| Ligand | BDBM50197834 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_609004 (CHEMBL1073146) |
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| IC50 | 1420±n/a nM |
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| Citation |  Hegde, VR; Borges, S; Patel, M; Das, PR; Wu, B; Gullo, VP; Chan, TM New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme. Bioorg Med Chem Lett20:1344-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4 |
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| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| BDBM50197834 |
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| n/a |
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| Name | BDBM50197834 |
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| Synonyms: | 2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-one | CHEMBL388956 | SCH-546909 | aristolactam AIIIa | aristololactam A IIIa |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11NO4 |
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| Mol. Mass. | 281.2628 |
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| SMILES | COc1c(O)cc2C(=O)Nc3cc4ccc(O)cc4c1c23 |
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| Structure | 
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