| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 4 |
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| Ligand | BDBM50307033 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_609338 (CHEMBL1072093) |
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| IC50 | 110±n/a nM |
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| Citation |  Li, G; Wang, D; Sun, M; Li, G; Hu, J; Zhang, Y; Yuan, Y; Ji, H; Chen, N; Liu, G Discovery and optimization of novel 3-piperazinylcoumarin antagonist of chemokine-like factor 1 with oral antiasthma activity in mice. J Med Chem53:1741-54 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 4 |
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| Name: | C-C chemokine receptor type 4 |
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| Synonyms: | C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41406.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51679 |
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| Residue: | 360 |
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| Sequence: | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
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| BDBM50307033 |
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| n/a |
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| Name | BDBM50307033 |
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| Synonyms: | 4-(5,7-Dihydroxy-4-methyl-2-oxo-2H-chromen-3-yl)-N-(4-(trifluoromethoxy)phenyl)piperazine-1-carboxamide | CHEMBL599995 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20F3N3O6 |
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| Mol. Mass. | 479.4059 |
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| SMILES | Cc1c(N2CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)c(=O)oc2cc(O)cc(O)c12 |
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| Structure | 
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