| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RAC-beta serine/threonine-protein kinase |
|---|
| Ligand | BDBM15211 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_608104 (CHEMBL1072809) |
|---|
| IC50 | 590±n/a nM |
|---|
| Citation |  McHardy, T; Caldwell, JJ; Cheung, KM; Hunter, LJ; Taylor, K; Rowlands, M; Ruddle, R; Henley, A; de Haven Brandon, A; Valenti, M; Davies, TG; Fazal, L; Seavers, L; Raynaud, FI; Eccles, SA; Aherne, GW; Garrett, MD; Collins, I Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). J Med Chem53:2239-49 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RAC-beta serine/threonine-protein kinase |
|---|
| Name: | RAC-beta serine/threonine-protein kinase |
|---|
| Synonyms: | AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55766.64 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 481 |
|---|
| Sequence: | MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
|
|
|
|---|
| BDBM15211 |
|---|
| n/a |
|---|
| Name | BDBM15211 |
|---|
| Synonyms: | CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[(2E)-3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide | N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H20BrN3O2S |
|---|
| Mol. Mass. | 446.361 |
|---|
| SMILES | Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
