BindingDB PrimarySearch

BDBM15211 CHEMBL104264::H-89::H89::HT-89 (H-89)::N-(2-{[(2E)-3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide::N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide

SMILES: Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1

InChI Key: InChIKey=ZKZXNDJNWUTGDK-NSCUHMNNSA-N

Data: 15 KI 23 IC50 4 Kd

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 42 hits for monomerid = 15211
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cAMP-dependent protein kinase (PKA) (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB PubMed	48	-10.1	n/a	n/a	n/a	n/a	n/a	n/a	30
Nagoya University School of Medicine					Assay Description Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...				J Biol Chem 265: 5267-72 (1990) BindingDB Entry DOI: 10.7270/Q2QR4VRF
Nagoya University School of Medicine					More data for this Ligand-Target Pair				3D Structure (crystal)
PKA (RAT)	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by PDSP K_i Database									J Pharmacol Exp Ther 316: 869-74 (2006) Article DOI: 10.1124/jpet.105.097303 BindingDB Entry DOI: 10.7270/Q2PN9464
Temple University Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Rho-associated protein kinase 2 (ROCK II) (Rattus norvegicus (Rat))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by PDSP K_i Database									J Pharmacol Exp Ther 316: 869-74 (2006) Article DOI: 10.1124/jpet.105.097303 BindingDB Entry DOI: 10.7270/Q2PN9464
Temple University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
cGMP-dependent protein kinase (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	480	-8.76	n/a	n/a	n/a	n/a	n/a	n/a	30
Nagoya University School of Medicine					Assay Description Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...				J Biol Chem 265: 5267-72 (1990) BindingDB Entry DOI: 10.7270/Q2QR4VRF
Nagoya University School of Medicine					More data for this Ligand-Target Pair
cGMP-dependent protein kinase (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by PDSP K_i Database									J Pharmacol Exp Ther 316: 869-74 (2006) Article DOI: 10.1124/jpet.105.097303 BindingDB Entry DOI: 10.7270/Q2PN9464
Temple University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Myosin light chain kinase, smooth muscle (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.83E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Binding affinity at MLCK				Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Myosin light chain kinase (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	2.83E+4	-6.30	n/a	n/a	n/a	n/a	n/a	n/a	30
Nagoya University School of Medicine					Assay Description Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...				J Biol Chem 265: 5267-72 (1990) BindingDB Entry DOI: 10.7270/Q2QR4VRF
Nagoya University School of Medicine					More data for this Ligand-Target Pair
Myosin light chain kinase, smooth muscle (Gallus gallus (chicken))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	2.83E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Biochemistry Curated by ChEMBL					Assay Description Inhibitory constant against MLCK				J Biol Chem 271: 26157-64 (1996) BindingDB Entry DOI: 10.7270/Q2BR8T3M
Institute for Biochemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase kinase 2 (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.97E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of CaM-KKbeta				Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
CAMK2B (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	2.97E+4	-6.28	n/a	n/a	n/a	n/a	n/a	n/a	30
Nagoya University School of Medicine					Assay Description Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...				J Biol Chem 265: 5267-72 (1990) BindingDB Entry DOI: 10.7270/Q2QR4VRF
Nagoya University School of Medicine					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	3.17E+4	-6.24	n/a	n/a	n/a	n/a	n/a	n/a	30
Nagoya University School of Medicine					Assay Description Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...				J Biol Chem 265: 5267-72 (1990) BindingDB Entry DOI: 10.7270/Q2QR4VRF
Nagoya University School of Medicine					More data for this Ligand-Target Pair
Casein kinase I isoform alpha (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.83E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of casein kinase 1				Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Casein kinase I isoform alpha (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	3.83E+4	-6.12	n/a	n/a	n/a	n/a	n/a	n/a	30
Nagoya University School of Medicine					Assay Description Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...				J Biol Chem 265: 5267-72 (1990) BindingDB Entry DOI: 10.7270/Q2QR4VRF
Nagoya University School of Medicine					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	1.37E+5	-5.36	n/a	n/a	n/a	n/a	n/a	n/a	30
Nagoya University School of Medicine					Assay Description Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...				J Biol Chem 265: 5267-72 (1990) BindingDB Entry DOI: 10.7270/Q2QR4VRF
Nagoya University School of Medicine					More data for this Ligand-Target Pair
Casein kinase II alpha (prime) (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	1.37E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Biochemistry Curated by ChEMBL					Assay Description Inhibitory constant against bovine CK2				J Biol Chem 271: 26157-64 (1996) BindingDB Entry DOI: 10.7270/Q2BR8T3M
Institute for Biochemistry Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of human PKBalpha expressed in SF9 cells				Biochem J 351: 95-105 (2001) BindingDB Entry DOI: 10.7270/Q24T6JKN
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5 (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of His-tagged human MSK1 expressed in Sf9 cells				Biochem J 351: 95-105 (2001) BindingDB Entry DOI: 10.7270/Q24T6JKN
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K) (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of His-tagged human S6K1 expressed in Escherichia coli				Biochem J 351: 95-105 (2001) BindingDB Entry DOI: 10.7270/Q24T6JKN
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of GST-tagged PKB/Akt1 incubated for 5 mins before eNOS substrate and ATP addition measured after 30 mins by kinase assay				Eur J Med Chem 46: 5949-58 (2011) Article DOI: 10.1016/j.ejmech.2011.10.006 BindingDB Entry DOI: 10.7270/Q2TD9XS3
Zhejiang University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase Pfmrk (Plasmodium falciparum)	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Research Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum Pfmrk				Bioorg Med Chem Lett 17: 4961-6 (2007) Article DOI: 10.1016/j.bmcl.2007.06.032 BindingDB Entry DOI: 10.7270/Q2GX4CC8
Institute of Research Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin) using ATP/eNOS as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by fluo...				Eur J Med Chem 73: 167-76 (2014) Article DOI: 10.1016/j.ejmech.2013.11.036 BindingDB Entry DOI: 10.7270/Q2BR8TNS
Zhejiang University Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of AKT1 (unknown origin) using ATP/eNOS as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by fluorescen...				Eur J Med Chem 75: 11-20 (2014) Article DOI: 10.1016/j.ejmech.2014.01.019 BindingDB Entry DOI: 10.7270/Q2KP83NK
Zhejiang University Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of ROCK2				Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of PKBbeta recombinant by radiometric filter binding assay				J Med Chem 51: 2147-57 (2008) Article DOI: 10.1021/jm701437d BindingDB Entry DOI: 10.7270/Q2X63NV8
The Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of GSK3-beta in human PC3M cells by ELISA				J Med Chem 51: 2147-57 (2008) Article DOI: 10.1021/jm701437d BindingDB Entry DOI: 10.7270/Q2X63NV8
The Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a
University of Tartu Curated by ChEMBL					Assay Description Displacement of fluorescent-ARC-1063 from His6-tagged recombinant human ROCK2 by luminescence intensity assay				Bioorg Med Chem Lett 22: 3425-30 (2012) Article DOI: 10.1016/j.bmcl.2012.03.101 BindingDB Entry DOI: 10.7270/Q2GT5P5N
University of Tartu Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of PKBbeta by radiometric filter binding assay				J Med Chem 53: 2239-49 (2010) Article DOI: 10.1021/jm901788j BindingDB Entry DOI: 10.7270/Q23B608V
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Torrey Pines Institute for Molecular Studies Curated by ChEMBL					Assay Description Inhibition of AKT3 by FRET based assay				Bioorg Med Chem Lett 19: 4634-8 (2009) Checked by Author Article DOI: 10.1016/j.bmcl.2009.06.078 BindingDB Entry DOI: 10.7270/Q2PV6KD4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Torrey Pines Institute for Molecular Studies Curated by ChEMBL					Assay Description Inhibition of AKT2 by FRET based assay				Bioorg Med Chem Lett 19: 4634-8 (2009) Checked by Author Article DOI: 10.1016/j.bmcl.2009.06.078 BindingDB Entry DOI: 10.7270/Q2PV6KD4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Torrey Pines Institute for Molecular Studies Curated by ChEMBL					Assay Description Inhibition of AKT1 by FRET based assay				Bioorg Med Chem Lett 19: 4634-8 (2009) Checked by Author Article DOI: 10.1016/j.bmcl.2009.06.078 BindingDB Entry DOI: 10.7270/Q2PV6KD4
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a
University of Tartu Curated by ChEMBL					Assay Description Displacement of fluorescent-ARC-1063 from His6-tagged recombinant human ROCK2 by luminescence intensity assay				Bioorg Med Chem Lett 22: 3425-30 (2012) Article DOI: 10.1016/j.bmcl.2012.03.101 BindingDB Entry DOI: 10.7270/Q2GT5P5N
University of Tartu Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK II) (Rattus norvegicus (Rat))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of rat ROCK2 expressed in Sf9 cells				Biochem J 351: 95-105 (2001) BindingDB Entry DOI: 10.7270/Q24T6JKN
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	7.5	25
Zhejiang University					Assay Description In vitro kinase assays were carried out using HTScan� PKB/Akt1 Kinase Assay kit (Cell Signaling Technology). Active recombinant Akt1 kinase (GST fusi...				Chem Biol Drug Des 85: 770-9 (2015) Article DOI: 10.1111/cbdd.12489 BindingDB Entry DOI: 10.7270/Q2TQ6085
Zhejiang University					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	662	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Chemistry in Estonia					Assay Description The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...				J Med Chem 52: 308-21 (2009) Article DOI: 10.1021/jm800797n BindingDB Entry DOI: 10.7270/Q2RX99FQ
Institute of Chemistry in Estonia					More data for this Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA) (Mus musculus (mouse))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Chemistry in Estonia					Assay Description The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...				J Med Chem 52: 308-21 (2009) Article DOI: 10.1021/jm800797n BindingDB Entry DOI: 10.7270/Q2RX99FQ
Institute of Chemistry in Estonia					More data for this Ligand-Target Pair				3D Structure (crystal)
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	31	n/a	n/a	n/a	7.5	30
Institute of Chemistry in Estonia					Assay Description The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...				J Med Chem 52: 308-21 (2009) Article DOI: 10.1021/jm800797n BindingDB Entry DOI: 10.7270/Q2RX99FQ
Institute of Chemistry in Estonia					More data for this Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA) (Mus musculus (mouse))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	n/a	23	n/a	n/a	n/a	7.5	30
Institute of Chemistry in Estonia					Assay Description The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...				J Med Chem 52: 308-21 (2009) Article DOI: 10.1021/jm800797n BindingDB Entry DOI: 10.7270/Q2RX99FQ
Institute of Chemistry in Estonia					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
UK Centre for Cancer Therapeutics					Assay Description The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...				Bioorg Med Chem 14: 1255-73 (2006) Article DOI: 10.1016/j.bmc.2005.09.055 BindingDB Entry DOI: 10.7270/Q2FN14F2
UK Centre for Cancer Therapeutics					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
UK Centre for Cancer Therapeutics					Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...				Bioorg Med Chem 14: 1255-73 (2006) Article DOI: 10.1016/j.bmc.2005.09.055 BindingDB Entry DOI: 10.7270/Q2FN14F2
UK Centre for Cancer Therapeutics					More data for this Ligand-Target Pair
cAMP-dependent protein kinase (PKA) (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of PKA-mediated phosphorylation of kemptide at 100 uM				Bioorg Med Chem Lett 16: 5360-3 (2006) Article DOI: 10.1016/j.bmcl.2006.07.078 BindingDB Entry DOI: 10.7270/Q2NG4TD5
St. Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	7.2	22
Astex					Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...				J Med Chem 50: 2289-92 (2007) Article DOI: 10.1021/jm0700924 BindingDB Entry DOI: 10.7270/Q2M32T1C
Astex					More data for this Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine))	BDBM15211 (CHEMBL104264 \| H-89 \| H89 \| HT-89 (H-89) \| N-(2-{[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	7.2	22
Astex					Assay Description The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...				J Med Chem 50: 2289-92 (2007) Article DOI: 10.1021/jm0700924 BindingDB Entry DOI: 10.7270/Q2M32T1C
Astex					More data for this Ligand-Target Pair				3D Structure (crystal)