| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin D2 receptor 2 |
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| Ligand | BDBM50308133 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_610068 (CHEMBL1072477) |
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| Ki | >224±n/a nM |
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| Citation |  Blouin, M; Han, Y; Burch, J; Farand, J; Mellon, C; Gaudreault, M; Wrona, M; Lévesque, JF; Denis, D; Mathieu, MC; Stocco, R; Vigneault, E; Therien, A; Clark, P; Rowland, S; Xu, D; O'Neill, G; Ducharme, Y; Friesen, R The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist. J Med Chem53:2227-38 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin D2 receptor 2 |
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| Name: | Prostaglandin D2 receptor 2 |
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| Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 43295.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5Y4 |
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| Residue: | 395 |
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| Sequence: | MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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| BDBM50308133 |
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| n/a |
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| Name | BDBM50308133 |
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| Synonyms: | 4-[(1R)-1-({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoic acid | CHEMBL591431 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16Cl3NO3S |
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| Mol. Mass. | 468.781 |
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| SMILES | C[C@@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(cc1)C(O)=O |r| |
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| Structure | 
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