Reaction Details |
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Target | Tyrosine-protein kinase HCK |
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Ligand | BDBM50311931 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_619934 (CHEMBL1113976) |
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IC50 | 65±n/a nM |
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Citation | Zhang, G; Ren, P; Gray, NS; Sim, T; Wang, X; Liu, Y; Che, J; Dong, W; Tian, SS; Sandberg, ML; Spalding, TA; Romeo, R; Iskandar, M; Wang, Z; Seidel, HM; Karanewsky, DS; He, Y Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II. Bioorg Med Chem Lett19:6691-5 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase HCK |
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Name: | Tyrosine-protein kinase HCK |
Synonyms: | HCK | HCK_HUMAN | Hematopoietic cell kinase | Hemopoietic cell kinase | p59-HCK/p60-HCK | p59Hck | p61Hck |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 59600.18 |
Organism: | Homo sapiens (Human) |
Description: | P08631 |
Residue: | 526 |
Sequence: | MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
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BDBM50311931 |
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n/a |
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Name | BDBM50311931 |
Synonyms: | CHEMBL1076469 | N-(3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(trifluoromethyl)benzamide |
Type | Small organic molecule |
Emp. Form. | C32H33F3N8O |
Mol. Mass. | 602.6526 |
SMILES | CN(C)CCCCNc1cc(ncn1)-n1c(Nc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)nc2ccccc12 |
Structure |
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